Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (2)
  • 2000-2004  (2)
  • Key words: Non-steroidal anti-inflammatory drugs (NSAIDs) – Meloxicam – COX-2 inhibitors – Gastric injury – Oxygen radical  (1)
  • decision support  (1)
  • 1
    ISSN: 1420-908X
    Keywords: Key words: Non-steroidal anti-inflammatory drugs (NSAIDs) – Meloxicam – COX-2 inhibitors – Gastric injury – Oxygen radical
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Aim and Design: In addition to a deficiency of endogenous prostaglandins due to inhibition of cyclo-oxygenase and a host of prostaglandin-mediated effects on mucosal protection, it has recently been proposed that neutrophil- and oxygen radical - dependent microvascular injuries may be important prime events that lead to mucosal injury induced by non-steroidal anti-inflammatory drugs. Therefore, we evaluated the role of oxygen free radicals in the pathogenesis of acute gastric ulceration induced by meloxicam, a preferential COX-2 inhibitor.¶Material: Studies were performed in Wistar rats.¶Treatment: Meloxicam was given by oral administration (3.75-30 mg/kg body weight).¶Methods: Determinations were made of gastric mucosal injury, xanthine-oxidase, myeloperoxidase and superoxide dismutase activities, as well as the effect of meloxicam on gastric prostaglandin synthesis (PGE2 levels) and glutathione homeostasis.¶Results: Oral administration of meloxicam dose-dependently (3.75-30 mg/kg) caused acute gastric haemorrhage erosions. The total area of gastric lesions increased with time until 24 hours after dosing. Xanthine-oxidase activity increased significantly after administration of the drug. Myeloperoxidase activity, as an index of neutrophil infiltration, as well as glutathione peroxidase, an important enzyme that scavenges lipid peroxides, were unaffected by meloxicam administration. In addition, superoxide dismutase activity, PGE2 and glutathione levels were significantly reduced.¶Conclusion: These results support the hypothesis that in addition to suppresion of prostaglandin synthesis, oxygen free radicals, probably derived via the action of xanthine oxidase, the decrease in superoxide dismutase activity, and the depletion of mucosal glutathione contribute to the pathogenesis of meloxicam-induced ulceration.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Precision agriculture 2 (2000), S. 377-388 
    ISSN: 1573-1618
    Keywords: decision support ; site-specific ; weed ; crop injury ; herbicide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract While uniform broadcast application (BC) of soil-applied herbicides is the norm, advances in geospatial technologies have enabled the deployment of site-specific herbicide application (SS). Since there are several, largely-untested decision rules for SS herbicide use, the objective of this work was to evaluate crop/weed outcomes and isoxaflutole use for a number of BC and SS strategies. Field experiments were established where isoxaflutole dose response functions were quantified from early-season Zea mays (L.), Sorghum bicolor (L.) Moench., and Abutilon theophrasti Medic. response data at multiple plots (64 in 1999; 62 in 2000) throughout a variable field. These data were then used to infer crop and weed outcomes from simulated application strategies. While BC and SS strategies that relied on the product label were similar in terms of total herbicide use, extent of crop tolerance, and A. theophrasti efficacy, the SS strategy resulted in a significant redistribution of herbicide. Using biologically effective doses (ED) resulted in the highest efficacy and herbicide use was highly species-dependent. By using a historical weed map of the field to guide herbicide application, herbicide use could be reduced some 20–48% when following the product label where seedlings were present, or 〉90% when using the ED for A. theophrasti. In order to maximize the potential agronomic benefits of SS, biological and spatial information of both the weed and soil should be taken into account.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...