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  • 1
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: In many parts of Europe there has been a net decline in the use of forage legumes since the 1980s, despite the reputed value of legumes for low-input livestock production systems. The political environment within which livestock farming in much of Europe operates (Common Agricultural Policy) is shifting the balance of economic advantage towards legumes and away from high usage of inorganic fertilizer. This has already been found for legume and grass–legume silages when compared with grass silages with a potential economic gain for farmers averaging 137 € ha−1, corresponding to an annual benefit for the European livestock farming sector of as much as € 1300 million.Recent literature has shown that legume-based grazing systems have the ability to reduce environmental problems by increasing the efficiency of N use and by avoiding a high transient surplus of soil mineral N. From the perspective of livestock nutrition, when forage legumes contain moderate levels of secondary compounds, such as condensed tannins and flavonoids, they offer considerable advantages including increased efficiency of N utilization within the digestive tract, reduced incidence of bloat hazard and higher resilience to parasites.Nevertheless, these benefits are partially counterbalanced in both temperate and Mediterranean regions by difficulties in establishment, maintenance and management under grazing. To gain knowledge on mixed grass–legume pastures, further research is required on: (i) the development of sustainable systems of livestock production which can maintain sward persistence and agricultural production under environmental stress; (ii) increasing knowledge of soil–plant–animal relations for a wide range of leguminous species, and under different soil types and climatic situations; and (iii) the benefits for consumers of food produced from low-input livestock production systems.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective:  The hygiene hypothesis suggests that the protective ‘siblings effect’ against atopic diseases such as atopic dermatitis, allergic asthma and hay fever is a result of recurrent infections during early childhood. A recent study and review have indicated that this protective effect may already arise in utero. Lower n-3 essential fatty acid (EFA) status is associated with increased parity, and EFA status has also been related to atopy. The present study confirms the negative association between parity and neonatal immunoglobulin E (IgE) levels and further unravel the role of perinatal EFA status.Methodology:  In a prospective cohort study in 184 atopic mothers and their neonates, we simultaneously measured serum total IgE and EFA levels in plasma phospholipids, both in the mother at 34–36 weeks of gestation and in the neonate at the age of 1 week. Linear regression analysis was used to estimate the effect of parity on maternal and neonatal IgE and EFA status, and the independent effects of parity and EFA status on IgE, controlling for confounding factors such as maternal age and birth season.Results:  Parity was associated with lower neonatal IgE level (P 〈 0.01), as well as with lower docosahexanoic acid (DHA, 22:6n-3) status of the mother (P = 0.01) but not of the neonate (P 〉 0.69). In the multivariate analysis, higher parity, higher maternal IgE, lower maternal age and birth in the first 3 months of the year were independently associated with neonatal IgE level. No association was detected between maternal or neonatal EFA status and neonatal IgE.Conclusions:  As neonatal total serum IgE is predictive of later atopy, our results support the hypothesis that the sibling effect in atopy is already being programmed in utero. Our data also confirm earlier findings that DHA status is lower in multiparous women, but this did not confound the relation between parity and neonatal IgE.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Barrett's oesophagus is the major risk factor for oesophageal adenocarcinoma. 5-Aminlevulinic acid-induced photodynamic therapy and argon plasma coagulation have been shown to be effective for ablating Barrett's oesophagus, but a comparative trial of these two modalities has not been reported.Aims : To compare photodynamic therapy and argon plasma coagulation for the ablation of Barrett's oesophagus.Methods : A total of 68 patients (54 male, 14 female; median age 61) with Barrett's oesophagus were randomized to photodynamic therapy (n = 34) or argon plasma coagulation (n = 34). Photodynamic therapy was performed using 5-aminlevulinic acid (30 mg/kg) and red light. Argon plasma coagulation was administered at a power setting of 65 W. Multiple treatment sessions were performed, with follow-up to 24 months.Results : All patients showed a macroscopic reduction in the area of Barrett's oesophagus. This was greatest in the argon plasma coagulation group with 33 of 34 (97%) ablated, compared with 17 of 34 (50%) in the photodynamic therapy group; in the remainder, there was a reduction in the length of Barrett's oesophagus (median 50%, range: 5–90). Buried glands were found in 24% of photodynamic therapy patients, and in 21% of argon plasma coagulation patients. The median follow-up is 12 months (range: 6–24).Conclusions : Photodynamic therapy and argon plasma coagulation are both effective for ablating Barrett's oesophagus. Argon plasma coagulation appears more effective than photodynamic therapy, but the impact of both on carcinoma development requires larger studies with long-term follow-up.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 321-332 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Systematic electron diffraction studies on intermetallic precipitates formed within a lightweight Mg–RE–Zn alloy (RE = La or Ce) identify these to be of structural type Mn12Th (space group I4/mmm). Analytical electron microscopy yields an overall composition of Mg12(LaxCe1−x) with x ̃0.43, with 1 at.% Zn incorporated within the lattice. Variations in characteristic X-ray emission rates, as an electron beam is rocked near zone-axis orientations, are used to form two-dimensional channelling patterns, termed X-ray incoherent channelling patterns. This channelling contrast enables a specific sublattice site that is occupied by Zn to be unambiguously identified within the Mg12RE lattice. The particular sublattice site is denoted by the Wyckoff letter f, and is one of the three different Mg sublattice sites f, i and j. Of these three sites, the Wigner–Seitz cell that is centred on the f sublattice site has the largest Mg–RE interatomic distance, and therefore the f site is expected to be favoured for accommodating the substitution of a larger Zn atom.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Recent evidence has shown that viable conidia from the fungus Penicillium chrysogenum induce allergic effects in mice. The present study was conducted to determine the specific allergic dose response of C57BL/6 mice to the protease extract, Pen ch, isolated from viable P. chrysogenum conidia.Methods:  Mice were treated with primary intraperitoneal (IP) injections of 10 or 100 μg of Pen ch adsorbed to alum, followed by weekly IP injections of 0.1, 1.0, or 10.0 μg Pen ch with alum for 4 weeks, and with 10.0 μg of Pen ch by intranasal (IN) inoculations the final 2 weeks before killing.Results:  Intraperitoneal injections of 10 and 100 μg of Pen ch for 5 weeks followed by 2 weeks of IN instillation of 10 μg induced significant increases of total serum immunoglobulin (Ig)E and IgG1. Bronchoalveolar lavage cell counts revealed increased numbers of eosinophils and neutrophils. Histopathological examination of lungs detected perivascular inflammation by eosinophils and neutrophils and increased mucous production.Conclusions:  The data presented in this study indicate that sensitization to protease allergens released by viable P. chrysogenum conidia in vivo induce a strong allergic inflammatory response in a murine model, which could have implications for people exposed to high levels of conidia of this organism.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2161
    Keywords: Key words Hemangiopericytoma ; Tibia ; MRI ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The Magnetic Resonance Imaging (MRI) appearances of primary osseous hemangiopericytoma (HPC) have been rarely described. We report on a 46-year-old Chinese man with primary osseous HPC of the right tibia. The characteristic vascular distribution of this tumor, presenting with a ”spoke-wheel” appearance on MR images and with angiographic correlation, is described. Although not pathognomonic, this MR appearance may be an important finding in suggesting the diagnosis of osseous HPC.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-198X
    Keywords: Key words Chronic renal failure ; Growth hormone treatment ; Bone mineral density ; Biochemical parameters of bone turnover ; Growth ; Body composition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Metabolic bone disease and growth retardation are common complications of chronic renal failure (CRF). We evaluated bone mineral density (BMD), bone metabolism, body composition and growth in children with CRF, and the effect of growth hormone treatment (GHRx) on these variables. Thirty-three prepubertal patients with CRF were enrolled including 18 children with growth retardation, who were treated with growth hormone for 2 years. Every 6 months, BMD of lumbar spine and total body, and body composition were measured by dual-energy X-ray absorptiometry. Biochemical parameters of bone turnover were assessed. Mean BMD of children with CRF did not differ from normal. During GHRx, BMD and bone mineral apparent density of lumbar spine and height SDS increased, whereas BMD of total body did not change. Lean body mass increased in the GH group. Alkaline phosphatase increased significantly in the GH group only. The other biochemical parameters of bone turnover increased in both groups, none of them correlated with the changes in BMD. No serious adverse effects of GHRx were reported. In conclusion, BMD of children with CRF did not differ from healthy children. Adequate treatment with α-calcidiol or the short duration of renal failure may have attributed to the absence of osteopenia in our patients. BMD of the axial skeleton and growth improved with GHRx.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 1045 -1046 
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopic surgery — Trocar injuries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Insertion of the first trocar during the ``closed'' technique of creating a pneumoperitoneum remains one of the most hazardous maneuvres in laparoscopic surgery, with complications such as major vascular and bowel injuries. The ease with which trocars are inserted through the abdominal wall may have some bearing on these complications. Methods: A range of both disposable and reusable trocars, which were identical in point cross section and size, were compared in an abdominal wall model reconstructed with animal hide, using a handheld pressure transducer. Multiple insertions were performed, and the results were expressed in pounds per square inch (PSI). Results: The disposable trocar tested required the least effort to insert (mean pressure, 2.76 PSI), followed by the new reusable (mean pressure, 3.42 PSI), with the used reusable trocar requiring the greatest force for insertion (mean pressure, 4.80 PSI). Conclusions: The effect of previous use on ease of insertion demonstrates an obvious disadvantage of reusable instruments. The excessive force required to insert some trocars may place the patient at greater risk of trocar injury.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1569-8041
    Keywords: adjuvant chemotherapy ; attitudes ; breast cancer ; consensus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:A worldwide variation in policy is seen regardingadjuvant systemic treatment for node negative breast cancer (NNBC). After thefirst presentations of the 10-year EBCTCG results, a study was carried out inthe Netherlands to assess patterns of care and to obtain the views ofoncologists as to what constitutes a worthwhile benefit from treatment. Methods:A questionnaire regarding patterns of use of andpreferences for adjuvant chemotherapy in younger women was mailed to surgical,medical and radiation oncologists in the Netherlands. Results:Thirty-five percent stated that NNBC patients under 50in their hospital never received adjuvant chemotherapy. The majorityconsidered a 10-year survival gain of 6%–10% sufficientto warrant the use of chemotherapy in patients under 50. Surgical oncologistsrequired a larger benefit from treatment than radiotherapists and medicaloncologists. The more frequently oncologists treated patients in a researchcontext, the less benefit they required from treatment to make it worthwhile. Conclusions:Data such as these are valuable input into theprocess of guideline development, and may help discussion within theprofession as to what benefit offsets the burden of treatment.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 92 (2002), S. 1752-1756 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We discuss the formation of pretilt by oblique irradiation of photosensitive polymers that homogeneously align liquid crystals in the direction corresponding to the maximum density of unreacted polymer. We show that a tilted polymer distribution is formed by oblique illumination with one beam of unpolarized or partially polarized light. When unpolarized radiation is used, a small azimuthal anisotropy is generated and the polymer tilt angle increases with incident angle. Pretilted liquid crystal alignment is possible up to a threshold angle at which the azimuthal alignment direction changes. Irradiation with partially polarized light gives a higher azimuthal anisotropy but smaller polymer tilt angles. We obtain liquid crystal pretilt angles up to 4° by oblique irradiation of polyimide with light from an excimer laser operating below the threshold for ablation. A simple two step process is used to obtain pretilted alignment for liquid crystals using surface gratings: a grating etched into polyimide by laser ablation is subsequently irradiated at oblique incidence to give planar liquid crystal alignment with a pretilt angle of 3°. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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