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Digitale Medien

Alterations in apolipoprotein B-48 in the postprandial state in NIDDM (1994)

Curtin, A. ; Deegan, P. ; Owens, D. ; [weitere]

Springer

Diabetologia 37 (1994), S. 1259-1264

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ISSN: 1432-0428

Schlagwort(e): Key words Apolipoprotein B-48 ; triglyceride-rich lipoproteins ; NIDDM ; cholesterol ; triglyceride.

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The intestine is a major site of cholesterol synthesis and produces apolipoprotein B-48, which is critical for intestinal cholesterol absorption and secretion. The purpose of this study was to examine postprandial changes in apolipoprotein B-48 in diabetes. Six non-insulin-dependent diabetic patients and six non-diabetic control subjects were given a high-fat meal (1300 kcal) and blood samples were taken pre- and postprandially, from which the triglyceride-rich lipoprotein fraction was isolated by ultracentrifugation (density 〈 1.006 g/ml). Apolipoprotein B-48 was separated on 4–15 % gradient gels and quantified as a percentage of the fasting concentration by densitometric scanning. Total protein, triglyceride and cholesterol in the triglyceride-rich lipoprotein fraction, blood glucose, and serum insulin were also measured. Diabetic patients exhibited a postprandial triglyceride-rich apolipoprotein B-48 profile significantly different from that of control subjects (p 〈 0.05). The triglyceride and total protein concentration in the triglyceride-rich lipoprotein fraction mirrored the post-prandial profile and apolipoprotein B-48 in both groups. Significantly different patterns for triglyceride (p 〈 0.02) and total protein (p 〈 0.05) following the fat-rich meal were observed in the two groups. Fasting and postprandial triglyceride-rich lipoprotein cholesterol and total apolipoprotein B were significantly higher in diabetic patients than in control subjects (p 〈 0.05). Since apolipoprotein B-48 is the structural protein of intestinally-derived lipoprotein particles, these studies suggest an abnormality in intestinal lipoprotein metabolism in diabetes. [Diabetologia (1994) 37: 1259–1264]

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00399800

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Digitale Medien

Heavy metals in Jamaican surface soils (1996)

Johnson, A. H. M. ; Lalor, G. C. ; Preston, J. ; [weitere]

Springer

Environmental geochemistry and health 18 (1996), S. 113-121

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ISSN: 1573-2983

Schlagwort(e): Heavy metals ; arsenic ; cadmium ; copper ; lead ; soils ; neutron activation analysis ; X-ray fluorescence atomic absorption spectrophotometry ; bauxite

Quelle: Springer Online Journal Archives 1860-2000

Thema: Geologie und Paläontologie , Medizin

Notizen: Abstract A regional survey of Jamaican surface soils has been conducted in which more than 200 samples were collected at a sample density of 1 per 64 km2 across the island and analysed for total concentrations of 31 elements by instrumental neutron activation analysis (INAA), energy dispersive X-ray fluorescence (EDXRF) analysis and atomic absorption spectrophotometry (AAS). The aim of the survey was to begin the construction of a high-precision geochemical database to provide information on elemental levels in soils for application to environmental studies, agriculture, and human and animal health. Results on the regional scale are presented for As, Cd, Cu, Hg and Pb. Although Jamaican surface soils are enriched in several heavy metals compared with world soil means and crustal abundances, lead is of particular importance at this stage because of its occurrence in residential areas. Except for Cu, the distribution maps of these elements are highly correlated with bauxite which in Jamaica is associated with white limestone geology and residualterra rossa soils.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01771287

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Digitale Medien

Elevated triglyceride-rich lipoproteins in diabetes (1996)

Curtin, A. ; Deegan, P. ; Owens, D. ; [weitere]

Springer

Acta diabetologica 33 (1996), S. 205-210

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ISSN: 1432-5233

Schlagwort(e): Key words Apolipoprotein B-48 ; Apolipoprotein B-100 ; Triglyceride-rich lipoprotein ; Non-insulin-dependent ; diabetes

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The role of the intestine in cholesterol metabolism in human diabetes is unclear, although abnormalities have been demonstrated in cholesterol synthesis and absorption in diabetic animals. This study examines the relationship between fasting and post-prandial apolipoprotein B-48 in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects. Eight type 2 diabetic patients and ten healthy non-diabetic control subjects were given a high-fat meal (1300 kcal), and the triglyceride-rich lipoprotein fraction was isolated by ultracentrifugation (d〈1.006 g/ml) from fasting and post-prandial plasma. Apolipoprotein B-48 and apo B-100 were separated on 4%–15% gradient gels and quantified by densitometric scanning with reference to a purified low-density lipoprotein (LDL) apo B-100 preparation. Diabetic patients had significantly higher concentrations of apo B-48 and apo B-100 in both the fasting (P〈0.05) and post-prandial (P〈0.001) triglyceride-rich lipoprotein samples compared with non-diabetic subjects. The diabetic patients also exhibited a significantly different post-prandial profile for apo B-48 and apo B-100, with a prolonged increase and a later post-prandial peak, than the non-diabetic subjects (P〈0.01). These results suggest that the raised fasting triglyceride-rich lipoproteins, often found in diabetes, are associated with apo B-48 and may be derived from increased intestinal chylomicron production. The post-prandial pattern suggests an abnormality in intestinal production as well as hepatic clearance of apo B-48 in type 2 diabetes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02048544

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Digitale Medien

Suspended particulates in the Jamaican atmosphere (1997)

Davis, M. ; Grant, C. ; Ho-Yorck-Krui, G. ; [weitere]

Springer

Environmental geochemistry and health 19 (1997), S. 0-0

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ISSN: 1573-2983

Schlagwort(e): Atmospheric particulates ; bromine ; Jamaica ; lead

Quelle: Springer Online Journal Archives 1860-2000

Thema: Geologie und Paläontologie , Medizin

Notizen: Abstract The results of a survey of air particulates at 23 sites across Jamaica for total suspended particulates (TSP), Al, Br, Cl, Na, Pb, and V, by instrumental neutron activation analysis (INAA) and X-ray fluorescence analysis (XRF) are reported. The geometric mean of TSP values, 35 g m-3, is well within the World Health Organisation's standard of 60 g m-3 for TSP, but in areas of high vehicular traffic density the TSP values exceeded this limit. The correlation coefficient between Br and Pb concentrations in the particulates was 0.92 and the Br/Pb ratio of 0.38 compares well with a ratio of 0.39 found in commercial petrol indicating that the exhaust from vehicular traffic is the major source of Pb in atmospheric particulate matter in Jamaica.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1018481901288

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