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  • Electronic Resource  (11)
  • 1995-1999  (6)
  • 1985-1989  (1)
  • 1920-1924  (1)
  • 1905-1909  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 57 (1907), S. 441-454 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 3 (1924), S. 1909-1912 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 4 (1998), S. 820-826 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Für Patienten mit Leukämie stellen Infektionen eine der Hauptursachen für Morbidität und Mortalität dar. Der bedeutendste Risikofaktor ist dabei die durch Chemotherapie bedingte Neutropenie. Im Folgenden sollen Maßnahmen in Prophylaxe, Therapie und Diagnostik von Infektionen bei Patienten mit Leukämien dargestellt werden, wobei das wesentlich intensivere Vorgehen bei allogen transplantierten Patienten nicht berücksichtigt ist.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Solar physics 122 (1989), S. 13-27 
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The flux density of a noise storm continuum is known to depend on importance parameters of the associated sunspot group, e.g., its total area A. A study of the continua at 287, 234, 113, and 64 MHz, however, reveals in case of the two cycles Nos. 20 and 21 that the radiation signatures of sunspot groups, with a value of A kept fixed, vary systematically with time indicating regular changes of relevant parameters of the overlying loop systems with the phase of the solar cycle. A trend of intense continua at high frequencies (for definition, cf. Figures 1, 2(b)) to occur preferably during the first activity maximum of a solar cycle has been obtained in either case suggesting a decrease of the emissivity of sunspot groups with time. Vice versa, intense continua at lower frequencies (for definition, cf. Figures 1, 2(b)) were mainly observed during the later phase of both cycles. The latter effect is shown to be attributed rather to a long-term variation of the spectral characteristics of the type-I continua than to an enhanced number of intense type-III continua. From the result obtained it follows that non-potential loops extending to great heights into the corona or developing at least conditions favourable for the generation of an intense type-I continuum even at the frequencies 〈 100 MHz tend to occur more frequently above sunspot groups during the later phase of a solar cycle than above the comparable groups of its first activity maximum. Furthermore, characteristic periods have been found for both cycles during which the emissivity, especially of the very large sunspot groups, was significantly diminished with reference to the comparable groups of the adjacent time intervals.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 71 (1995), S. 311-312 
    ISSN: 1432-0584
    Keywords: Itraconazole ; Vinca alkaloids ; Neurotoxicity ; MDR ; Cytochrome P-450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In four of 14 patients with acute lymphoblastic leukemia (ALL) who received induction chemotherapy containing weekly injections of vincristine and simultaneous antifungal prophylaxis with itraconazole, unusually severe and early vincristine-induced neurotoxicity was observed. In these patients (three female, one male) paresthesia and muscle weakness of the upper/lower extremities and paralytic ileus occurred after the first or second vincristine injection. In one patient a laryngeal nerve paresis required mechanical ventilation. The neurotoxic complications were more serious than those seen in a previous series of 460 ALL patients under the identical cytostatic regimen but without itraconazole prophylaxis. The underlying mechanism is unclear. Interaction with the cytochrome P-450 system, reversal of multidrug resistance, and influence of estrogens are to be considered.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 71 (1995), S. 311-312 
    ISSN: 1432-0584
    Keywords: Key words Itraconazole ; Vinca alkaloids ; Neurotoxicity ; MDR ; Cytochrome P-450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In four of 14 patients with acute lymphoblastic leukemia (ALL) who received induction chemotherapy containing weekly injections of vincristine and simultaneous antifungal prophylaxis with itraconazole, unusually severe and early vincristine-induced neurotoxicity was observed. In these patients (three female, one male) paresthesia and muscle weakness of the upper/lower extremities and paralytic ileus occurred after the first or second vincristine injection. In one patient a laryngeal nerve paresis required mechanical ventilation. The neurotoxic complications were more serious than those seen in a previous series of 460 ALL patients under the identical cytostatic regimen but without itraconazole prophylaxis. The underlying mechanism is unclear. Interaction with the cytochrome P-450 system, reversal of multidrug resistance, and influence of estrogens are to be considered.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Key words AML ; Idarubicin ; HDara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The toxicity and outcome after high-dose ara-C/daunorubicin (HDara-C/DNR) consolidation therapy in de novo AML was compared in 11 patients who received an idarubicin-containing induction therapy (IDA; from June 1995 to March 1997) and 16 patients pretreated with daunorubicin (DNR; from July 1990 to May 1995) for induction. The DNR group consisted of two cohorts, one (n=6) of patients who had received, as had the IDA group, two induction and one intermediate-dose ara-C consolidation courses, and another (n=10) of patients who had been pretreated with one induction and one consolidation course prior to HDara-C/DNR. There was no difference in the relative dose between the three cohorts. Following HDara-C/DNR, the IDA-pretreated patients experienced a more prolonged myelosuppression during consolidation therapy compared with the DNR group. Duration of neutropenia (〈500 neutrophils/μl) following HDara-C/DNR was 31.2 ± 16 days (mean ±SEM) in the IDA group compared with 18.7 ± 5 days in the DNR group (p〈.001 Mann-Whitney U-test). The duration of thrombocytopenia (platelets 〈25 000/μl) was 34.8 ± 20 days in the IDA group vs. 18.5 ± 6 days in the DNR group (p〈.005). The more prolonged myelosupression was associated with a longer duration of fever (18.9 ± 24 vs. 6.9 ± 5.2 days). A greater incidence, length (11 ± 8 vs. 1.2 ± 2 days), and severity of diarrhea were observed in the IDA-pretreated group. Three of 11 IDA patients experienced WHO grade III-IV diarrhea. In the IDA group two patients developed severe enterocolitis with Candida septicemia, and one of these patients died. One patient in the IDA group died during prolonged aplasia. In the DNR group 6/16 patients experienced grade I-II diarrhea. Two patients in each group died during consolidation therapy. The CR rate was 87% in the IDA group and 79% in the DNR group. Relapse-free survival after HDara-C is 50% at a median follow-up of 60 months in the DNR group and 45% after a median follow-up of 17 months in the IDA group. Whether the advantage of the superior response rate in the IDA-treated patients may be lost during HDara-C consolidation treatment due to increased toxicity remains to be proven in larger trials.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 77 (1998), S. 235-238 
    ISSN: 1432-0584
    Keywords: Key words Non-Hodgkin's lymphoma ; Eosinophilia-myalgia syndrome ; Eosinophilic fasciitis ; l-tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of l-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone, and there was an intermittent clinical remission of CLL with absence of the monoclonal B-cell population. A few years later, the B-CLL relapsed, but without sign and symptoms of EMS. Whereas other eosinophilic syndromes such as eosinophilic fasciitis, panniculitis, or cellulitis Wells have been found to occur in relation to malignant underlying diseases, only a single patient with malignant fibrous histiocytoma following EMS has been described. There are no reports about an increased occurrence of B-CLL or other non-Hodgkin's lymphomas combined with or following EMS or related to l-tryptophan itself. The variant types of eosinophilic syndromes occurring due to malignant disorders, the differentiation from EMS, and the possible association between B-CLL and l-tryptophan-related EMS are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 52 (1905), S. 346-369 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 52 (1906), S. 97-110 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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