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  • Electronic Resource  (19)
  • 1995-1999  (17)
  • 1955-1959  (1)
  • 1945-1949  (1)
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  • Electronic Resource  (19)
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  • 1
    Electronic Resource
    Electronic Resource
    Volumetric Determination of Calcium in Presence of Phosphate (1959)
    s.l. : American Chemical Society
    Analytical chemistry 31 (1959), S. 1230-1233 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60151a001
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  • 2
    Electronic Resource
    Electronic Resource
    Neutrophil function in women with pre-eclampsia (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the function of neutrophils in normal pregnancy and pre-eclampsia.Design Baseline levels and activated responses of peripheral blood neutrophils were measured in response to the physiological agonists, n-formyl-met-leu-phe (fMLP) and zymosan activated serum.Sample Neutrophils of 16 pre-eclamptic, 17 normal pregnant (third trimester) and 15 nonpregnant age-matched control women were calculated.Setting Antenatal Clinic, City Hospital, Nottingham.Methods Neutrophil superoxide anion production was determined by lucigenin-enhanced chemilumi-nescence; the release of secondary granule lactoferrin by ELISA; and the expression of cell surface adhesion molecules CD1 1b, CD 18 and L-selectin (CD62L) by flow cytometric analysis.Results Superoxide anion generation was reduced in the pregnant group compared with nonpregnant controls [fMLP by 51 % (P= 0.03) and zymosan activated serum by 56% (P= 〉 0.01)] but pre-eclamptic measurements did not show a similar reduction. There were no differences between the three study groups in the plasma levels of lactofenin, or in the stimulated expression and release of CD1 Ib and CD18, or lactoferrin and L-selectin. The base-line levels for the production of superoxide anions; the expression of CD11b or CD 18 or L-selectin; and the release of lactofemn showed no significant differences.Conclusions Circulating neutrophils in pregnancy and pre-eclampsia are neither activated nor primed in vivo, however the release of reactive oxygen species is diminished in normal pregnancy. In comparison, an elevation of reactive oxygen generation in pre-eclampsia may highlight a role for neutrophils in the oxidative stress and pathophysiology of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08404.x
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  • 3
    Electronic Resource
    Electronic Resource
    Maternal and fetal angiotensinogen gene allele sharing in pre-eclampsia (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare the angiotensinogen genotypes in normotensive and pre-eclamptic pregnancies in maternal and fetal samples.Design Prospective observational study.Setting University Hospital, Queen's Medical Centre, Nottingham.Population Forty-three women with pre-eclampsia and 84 normotensive pregnant women. Fetal samples were available for genotyping from 96% of the pregnancies.Methods Maternal and fetal DNA was genotyped at angiotensinogen codon 235 and at a dinucleotide repeat polymorphism in the 3′ flanking region of the gene. Angiotensinogen and renin concentrations were measured in maternal plasma by radioimmunoassay.Results In contrast to earlier studies, no association was demonstrated between the angiotensinogen 235 Thr variant and pre-eclampsia. Normotensive pregnant women homozygous for this variant had significantly lower plasma angiotensinogen concentrations (median 2.2 ng AI/mL; IQR 1.8–3.0) than women homozygous for the 235 Met allele (3.6 ng AI/mL; IQR 2.5–4.1; P= 0.04). In pre-eclamptic pregnancies, 79% (11/14) of mothers heterozygous for the dinucleotide repeat allele designated A9 transmitted this allele to the fetus, more frequently than would be expected by chance (P= 0.02). The A9 allele was associated with low plasma angiotensinogen concentrations (P= 0.001) and high renin concentrations (P= 0.02) in normotensive women.Conclusions There is no evidence that the angiotensinogen 235 Thr allele is associated with pre-eclampsia in the Nottingham population. The angiotensinogen 235 Thr allele is associated with low plasma angiotensinogen concentrations in normotensive pregnant women, in contrast to the high levels associated with this variant in non-pregnant women, suggesting that regulation of angiotensinogen expression in normal pregnancy may differ significantly from that in the non-pregnant state. There is preliminary evidence that maternal-fetal transmission of an angiotensinogen allele associated with low plasma angiotensinogen concentrations is associated with pre-eclampsia. Impaired generation of angiotensin II at the maternal-fetal interface may be a factor in the pathogenesis of pre-eclampsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08238.x
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for a circulating factor in pre-eclampsia. A role for vascular endothelial growth factor? (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb09981_29.x
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  • 5
    Electronic Resource
    Electronic Resource
    Smoking a cigarette has no effect on visual temporal order discrimination in regular smokers (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction 91 (1996), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: A temporal order discrimination task was performed by 20 regular smokers who were tested with and without a pre-test cigarette in a repeated measures design following overnight abstinence. Subjects mere asked to discriminate the temporal order of the rapid sequential illumination of two lights positioned equidistant from a central fixation point. None of the measures of performance in this task were significantly affected by smoking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.1996.91687913.x
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  • 6
    Electronic Resource
    Electronic Resource
    Diiodobis(η5-trimethylsilylcyclopentadienyl)titanium(IV) (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 2168-2170 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196006221
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  • 7
    Electronic Resource
    Electronic Resource
    The deep structure of a sea-floor hydrothermal deposit (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 392 (1998), S. 485-488 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Hydrothermal circulation at the crests of mid-ocean ridges plays an important role in transferring heat from the interior of the Earth. A consequence of this hydrothermal circulation is the formation of metallic ore bodies known as volcanic-associated massive sulphide deposits. Such ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/33126
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  • 8
    Electronic Resource
    Electronic Resource
    Crystallization of glycerol dehydrogenase from Bacillus stearothermophilus (1995)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 830-832 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The NAD+-linked glycerol dehydrogenase from Bacillus stearothermophilus is a member of the so-called `iron- containing' class of polyol dehydrogenases. This enzyme has been crystallized in three different forms in the presence of a range of divalent cations and glycerol or NAD+ using the hanging-drop method of vapour diffusion with ammonium sulfate as the precipitant. X-ray photographs have established that the crystals grown in the presence of zinc and glycerol (form A) most likely belong to space group I4122 with cell parameters a = b = 102 and c = 728 Å. The crystals grown with zlnc and NAD+ (form B) belong to the tetragonal system and probably belong to the space group P4212 with cell parameters a = b = 150 and c = 220 Å. The crystals grown with lead and glycerol (form C) belong to a primitive orthorhombic system with cell parameters a = 127, b = 178 and c = 173 Å. Experiments using the synchrotron radiation source at the DRAL Daresbury laboratory have shown all three crystal types diffract to at least 3 Å resolution. Elucidation of the three-dimensional structure of this enzyme will provide a structural framework for this class of polyol dehydrogenases, which are not represented in the database at present, and enable comparisons to be made with enzymes belonging to the other classes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444994013533
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  • 9
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray studies of nitrogenase component 1 (the MoFe protein) from Klebsiella pneumoniae (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 227-228 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Two crystal forms of component 1 (the MoFe protein) of nitrogenase from Klebsiella pneumoniae have been isolated and characterized. The triclinic form has cell dimensions a = 76.0, b = 109.6, c = 144.6 Å, α = 80.3, β = 74.9 and γ = 69.6°, diffracts to around 3.0 Å and has two molecules in the asymmetric unit. The monoclinic form belongs to space group P21 with a = 76.6, b = 127.8, c = 109.1 Å and β = 104.6° (frozen at 100 K), diffracts to 1.5 Å and has one molecule in the asymmetric unit. At this resolution the outstanding questions concerning the structure and the operation of the enzyme, in particular the linkage between the Fe4S4 units in the P clusters, the true geometry of the apparently trigonal Fe atoms in the FeMoco and the reduction site itself, should be answerable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444996012681
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  • 10
    Electronic Resource
    Electronic Resource
    Crystallization of NAD+-dependent phenylalanine dehydrogenase from Nocardia sp239 (1998)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 269-272 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The NAD+-dependent phenylalanine dehydrogenase from Nocardia sp239 has been crystallized by the hanging-drop method of vapour diffusion using ammonium sulfate as the precipitant. Two crystal forms were obtained in the presence and absence of the enzyme substrates phenylpyruvic acid or phenylalanine and its coenzyme NADH. Crystals of the native protein belong to the hexagonal system, with the space group being one of the enantiomorphic pair P6122 or P6522. The cell dimensions are a = b = 111.0, c = 174.5 Å, α = β = 90 and γ = 120°. Crystals grown from the protein co-crystallized with its substrates all belong to the trigonal system, space group P3121 or P3221, with unit-cell dimensions of a = b = 88.1 , c = 112.6 Å, α = β = 90 and γ = 120°. Preliminary protein-sequencing experiments have established that this enzyme is related to the octameric PheDH's which are members of the wider superfamily of amino-acid dehydrogenases. However, gel-filtration studies suggest that this enzyme is active as a monomer. The full determination of the three-dimensional structure of this phenylalanine dehydrogenase will add to the understanding of the molecular basis of the differential substrate specificity within this enzyme superfamily. In turn this will contribute to the rational design of an amino-acid dehydrogenase which could be used for the diagnosis of phenylketonuria and for the chiral synthesis of high-value pharmaceuticals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444997009980
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