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  • 1
    Electronic Resource
    Electronic Resource
    Decreasing diffusion limitation on exercise in lower-graded interstitial lung disease (1998)
    Springer
    Pflügers Archiv 435 (1998), S. 762-766 
    Details
    ISSN: 1432-2013
    Keywords: Key words Isotopic analysis ; Overall fractionation factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In this study we investigated the contribution of diffusion limitation to the exercise-induced hypoxaemia in interstitial lung disease (ILD). We applied isotopic analysis to the composition of the stable isotopic oxygen molecules 16O2 and 16O18O in expiratory gas mixtures obtained from six ILD patients and six healthy subjects at rest and during ergometer work (60 W). The changes in the 16O18O/16O2 ratios were interpreted by using the overall fractionation factor of respiration (α O) which would be increased towards 1.03 on increasing diffusion limitation. In addition, the O2 partial pressures of alveolar gas and arterial blood (P AO2, P aO2) were determined. In the patients, α O was significantly reduced from 1.0066 ± 0.0004 (mean ± SD) at rest to 1.0035 ± 0.0004 during exercise and in the healthy subjects from 1.0072 ± 0.0008 to 1.0044 ± 0.0004. Furthermore, the exercise-induced reduction of P aO2 (from 77 to 69 mmHg) was due to a drop of alveolar PO2 found in each patient, whereas in each healthy subject P aO2 was increased on exercise. On the basis of a resistance model we conclude that the patients’ data were inconsistent with increasing diffusion limitation but showed an increasing impairment of O2 transport by ventilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050581
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of heat-shock protein 60 immunoreactivity in testes of infertile men (1997)
    Springer
    Cell & tissue research 288 (1997), S. 539-544 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Testis ; hsp60 ; Infertility ; Spermatogonia ; Immunohistochemistry ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The immunohistochemical localization of heat-shock protein 60 (hsp60) was investigated in testicular biopsies obtained from 121 adult men with disturbed fertility. In normal unaffected tubules, hsp60 immunoreactivity was localized to spermatogonia, primary spermatocytes and Sertoli cells. In spermatogonia, cytosolic and mitochondrial labelling could be differentiated. In general, the number of stained spermatogonia decreased with the loss of spermatogenic function. A significant (P〈0.01) reduction of stained spermatogonia was observed in testes with maturation arrest of spermatogenesis at the level of primary spermatocytes (30.2±21.6%) compared with testes exhibiting normal spermatogenesis. In addition, the decrease in the score correlated significantly with the diminution of cytosolic hsp60 immmunolabelling (coefficient r=0.25, P=0.03). There was a significant difference (P〈0.01) in the percentage of cytosolic-stained spermatogonia in testes with a score equal to or greater than 5 (14.7±9.8%) and a score less than 5 (8.9±6.9%). These observations suggest that a low level of hsp60 expression in spermatogonia may lead to a different pattern of protection, which in turn could be involved in low spermatogenic efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050839
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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