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  • Electronic Resource  (2)
  • 1995-1999  (2)
  • 3-D cell culture  (1)
  • Anterior spinal artery syndrome  (1)
Material
  • Electronic Resource  (2)
Years
  • 1995-1999  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Chirurg 68 (1997), S. 902-905 
    ISSN: 1433-0385
    Keywords: Key words: Carcinoma of esophagus ; Anterior spinal artery syndrome ; Transesophageal echocardiography. ; Schlüsselwörter: Oesophaguscarcinom ; Spinalis-anterior-Syndrom ; transoesophageale Echokardiographie.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Wir berichten über den Fall eines Patienten mit Oesophaguscarcinom des mittleren Drittels im klinischem Stadium III, der nach kurativer thoracoabdomineller Oesophagusresektion eine Paraparese beider Beine mit Sensibilitätsausfall ab TH12/L1 und zusätzlich dissoziierter sensomotorischer Empfindungsstörung ab C6/C7 rechts sowie ab TH5 links entwickelte. Ursache war offenbar die Abschilferung eines Aortenwandplaques mit partieller Verlegung der A. radicularis magna (Adamkiewicz) bei bekannter fortgeschrittener Arteriosklerose. In der Literatur ist das Spinalis-anterior-Syndrom überwiegend nach Operationen der thorakalen Aorta beobachtet worden und nicht nach Eingriffen an der Speiseröhre. Über diese seltene, aber schwerwiegende Komplikation bedarf es vor Oesophaguseingriffen keiner zusätzlichen Aufklärung.
    Notes: Summary. We report a case of postoperative paraplegia resembling an anterior spinal artery syndrome after curative esophagectomy in a patient with carcinoma of esophagus and clinical stage III (UICC). Neurologic deficit was characterized by loss of sensibility at the level of T12/L1 together with paraparesis of both lower extremities. Furthermore, dissociated sensorimotor depletion at C6/C7 (rightsided) and at T5 (leftsided) was noted. This severe complication was most probably caused by peeling of an arteriosclerotic plaque of the thoracic aorta due to preexisting advanced arteriosclerosis, leading to a partial occlusion of the great radicular artery of Adamkiewicz. Even though anterior spinal artery syndrome is a well-known problem in the operative management of thoracic aortic aneurysms, this complication has not previously been reported after esophagectomy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0197-8462
    Keywords: electromagnetic field ; myositis ossificans ; osteoblastic cells ; in vitro ; 3-D cell culture ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Human osteoblastic cells were grown in a three-dimensional (3-D) cell culture model and used to test the effects of a 20 Hz sinusoidal electromagnetic field (EMF; 6 mT and 113 mV/cm max) on collagen type I mRNA expression and extracellular matrix formation in comparison with the effects of growth factors. The cells were isolated from trabecular bone of a healthy individual (HO-197) and from a patient presenting with myositis ossificans (MO-192) and grown in a collagenous sponge-like substrate. Maximal enhancement of collagen type I expression after EMF treatment was 3.7-fold in HO-197 cells and 5.4-fold in MO-192 cells. Similar enhancement was found after transforming growth factor-β (TGF-β) and insulin-like growth factor-I (IGF-I) treatment. Combined treatment of the cells with EMF and the two growth factors TGF-β and IGF-I did not act synergistically. MO-192 cells produced an osteoblast-characteristic extracellular matrix containing collagen type I, alkaline phosphatase, and osteocalcin, together with collagen type III, TP-1, and TP-3, two epitopes of an osteoblastic differentiation marker. The data suggest that the effects of EMFs on osteoblastic differentiation are comparable to those of TGF-β and IGF-I. We conclude that EMF effects in the treatment of skeletal disorders and in orthopedic adjuvant therapy are mediated via enhancement of collagen type I mRNA expression, which may lead to extensive extracellular matrix synthesis. Bioelectromagnetics 19:222-231, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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