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  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Alzheimer-Erkrankung ; Visuokonstruktive Störung ; Zeichnen ; Demenzausprägung ; Key words Alzheimer’s disease ; Visuo-constructive impairment ; Drawing ; Severity of dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this study we assessed the drawing abilities in 37 patients with probable Alzheimer’s disease according to NINCDS-ADRDA criteria. Drawing abilities (drawing: house, flower, clock; Rey-Osterrieth figure; copying: MMST-figure; Rey-Osterrieth figure) were quantified with different rating schemes and related to other neuropsychological assessments. All patients underwent a positron emission tomography with 18-FDG. Drawing performance was highly correlated with severity of dementia – expressed in MMST scores (r=0.78; p〈0.0001) – with visuo-spatial short-term memory (r=–0.69; p=0.001), and writing abilities (r=–0.77; p〈0.0001). The summarized drawing score showed a statistically significant correlation with the rate of temporoparietal glucose metabolism measured with positron emission tomography and 18-FDG (r=0.39; p=0.017). In the drawings of AD patients omittings and simplifications were typical, whereas perseverations rarely occured. In severely demented patients closing-in phenomenons could be de- scribed, too. A subgroup of AD patients with visuo-constructive impairment as the leading symptom could not be identified.
    Notes: Zusammenfassung Bei 37 Patienten mit der wahrscheinlichen Alzheimer-Erkrankung (AD) nach NINCDS-ADRDA-Kriterien wurden die Zeichenleistungen (freies Zeichnen: Haus, Blume, Uhr; Rey-Osterrieth-Figur; Abzeichnen: MMST-Figur; Rey-Osterrieth Figur) untersucht und mit anderen neuropsychologischen Tests verglichen. Bei allen Patienten wurde weiterhin eine Positronen-Emissions-Tomographie mit 18-FDG durchgeführt. Die Zeichenleistungen der Patienten waren hoch mit der Demenzausprägung, ausgedrückt in MMST-Werten, korreliert (r=0,78; p〈0,0001) und wiesen einen engen Zusammenhang zur visuospatialen Kurzzeitgedächtnisspanne (r=–0,69; p=0,001) und zur Schreibleistung (r=–0,77; p〈0,0001) auf. Der summierte Zeichenscore wies einen statistisch signifikanten Zusammenhang mit der temporoparietalen Stoffwechselrate – gemessen mit PET und FDG – auf (r=0,39; p=0,017). Bei den Zeichnungen der AD-Patienten zeigten sich v.a. Auslassungen und Vereinfachungen. Perseverationen kamen selten vor. Bei schwer dementen Patienten ließen sich auch Closing-in-Phänomene beobachten. Eine Subgruppe von AD-Patienten, bei denen visuokonstruktive Störungen die Leitsymptomatik ihrer Demenz waren, ließ sich nicht identifizieren.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Brain, MR ; Positron imaging ; Dementia ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the correlation of PET and MRI with neuropsychological tests in 26 patients with probable Alzheimer's disease (AD). The width of the temporal horns and the third ventricle, regional metabolic rates of glucose (rCMRGlu) and the proportion of cerebrospinal fluid space in mesial temporal and temporoparietal cortical regions were measured with three-dimensionally coregistered PET and MRI in two planes perpendicular to the Sylvian fissure. Highly significant correlations between rCMRGlu and neuropsychological tests were found mainly in the temporoparietal cortex, with and without correction for atrophy. Correlations of similar magnitude were seen also between most tests and the width of the temporal horns and third ventricle. Changes in the third ventricle and mesial temporal lobe were best seen with MRI, whereas PET most clearly depicted alterations in neocortical association areas. These two aspects of the disease correlated with the severity of dementia to a similar degree.
    Type of Medium: Electronic Resource
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