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  • Electronic Resource  (6)
  • 1995-1999  (6)
  • Drug discrimination  (2)
  • Highest corner  (2)
  • Syzygies  (2)
  • Chemistry
  • Mice
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Material
  • Electronic Resource  (6)
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    On an implementation of standard bases and syzygies in SINGULAR (1996)
    Springer
    Applicable algebra in engineering, communication and computing 7 (1996), S. 235-249 
    Details
    ISSN: 1432-0622
    Keywords: Standard bases ; Syzygies ; Computer algebra system ; Highest corner ; EcartMethod
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract We describe an implementation of a general standard basis algorithm, valid for any monomial ordering compatible with the natural semigroup structure. We concentrate on new strategies which have proved useful, in particular in the non-wellordering case. Moreover, we describe the first implementation of Schreyer's method to compute syzygies and compare it with other, more classical methods. Comparisons of the computing time of several examples in the system SINGULAR give hints as to which strategies should be used in different classes of examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190332
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On an Implementation of Standard Bases and Syzygies in SINGULAR (1996)
    Springer
    Applicable algebra in engineering, communication and computing 7 (1996), S. 235-249 
    Details
    ISSN: 1432-0622
    Keywords: Key words Standard bases ; Syzygies ; Computer algebra system ; Highest corner ; EcartMethod.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract  We describe an implementation of a general standard basis algorithm, valid for any monomial ordering compatible with the natural semigroup structure. We concentrate on new strategies which have proved useful, in particular in the non-wellordering case. Moreover, we describe the first implementation of Schreyer’s method to compute syzygies and compare it with other, more classical methods. Comparisons of the computing time of several examples in the system SINGULAR give hints as to which strategies should be used in different classes of examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190332
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist (1995)
    Springer
    Psychopharmacology 120 (1995), S. 483-490 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ABT-418 ; Antinociception ; Hypothermia ; Locomotor activity ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract ABT-418, a novel cholinergic ligand, was reported to possess potent cognitive-enhancing and anxiolytic properties in animal models with reduced side effects (Decker et al. 1994; Garvey et al. 1994) suggesting selectivity of effects. In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated in different tests in laboratory animals. ABT-418 binds with high affinity to3H-nicotine binding sites in the brain with, however, a Ki (6 nM) less than that of nicotine (four-fold). In addition, it acts as a full nicotinic agonist in producing hypomotility, hypothermia and antinociception in mice and engendering nicotine-like responding in rat drug discrimination. The potency of ABT-418 is three to four times less than that of nicotine in all of the animal models, except for hypothermia. In addition, its behavioral effects are completely blocked by mecamylamine, a non-competitive nicotinic antagonist. Although activation of nicotinic receptors by ABT-418 produced several behavioral and pharmacological effects, our results do not suggest high selectivity of different effects as reported by Decker et al. (1994) and Garvey et al. (1994). However, it should be noted that we did not perform some of these tests that produced effects at low doses (Decker et al. 1994) and additional pharmacological studies are needed to establish its selectivity at multiple nicotinic receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245822
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice (1995)
    Springer
    Psychopharmacology 117 (1995), S. 67-73 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine dihydro-β-erythroidine ; Antinociception ; Calcium ; Mecamylamine ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The comparative in vivo pharmacology of mecamylamine and dihydro-β-erythroidine (DHβE) in mice was studied. Modulation of the behavioral effects (antinociception, hypomotility, motor impairment and hypothermia) of nicotine in mice by DHβE and mecamylamine were carried out. After SC administration, DHβE and mecamylamine were nearly equipotent in blocking nicotine's effects except for antinociception, in which mecamylamine was clearly more potent. Intrathecal injection of DHβE was also effective in blocking the antinociceptive effect of nicotine. In vivo interaction of DHβE with calcium and calcium channels, involved in the central actions of nicotine, showed that intrathecal administration of DHβE failed to reduce the antinociception induced by diverse drugs which increase intracellular calcium such as thapsigargin, (±)-BAYK 8644 and calcium, indicating that this antagonist does not affect calcium-dependent mechanisms involved in antinociception. On the other hand, mecamylamine blocked the antinociceptive effect of the calcium modulatory drugs, suggesting that it may be acting on calcium-dependent mechanisms involved in the intracellular signaling process. We conclude that DHβE, a nicotinic neuromuscular antagonist, is able to block some of the central actions of nicotine after systemic and intrathecal administration. The mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of DHβE on nicotine receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245100
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacological specificity of Δ9-tetrahydrocannabinol discrimination in rats (1995)
    Springer
    Psychopharmacology 118 (1995), S. 419-424 
    Details
    ISSN: 1432-2072
    Keywords: Δ9-THC ; Drug discrimination ; Benzodiazepines ; Specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While many previous studies have shown that a variety of cannabinoids substitute and cross-substitute for Δ9-tetrahydrocannabinol (THC) in drug discrimination procedures, few have systematically examined potential THC-like effects of non-cannabinoid compounds. The purpose of the present study was to delineate further the pharmacological specificity of THC discrimination. Rats were trained to discriminate THC (3.0 mg/kg) from vehicle. Following determination of a dose-effect curve with THC, substitution tests with selected compounds from a variety of pharmacological classes, includingl-phenylisopropyl adenosine, dizocilpine, dextromethorphan, clozapine, buspirone, MDL 72222, muscimol, midazolam and chlordiazepoxide, were performed. Whereas THC produced full dose-dependent substitution, substitution tests with non-cannabinoid drugs resulted in less than chance (50%) levels of responding on the THC-appropriate lever, with the exception of (+)-MDMA (2.5 mg/kg, 50%) and diazepam (3.0 mg/kg, 67%). These results are consistent with those of previous studies and suggest that the discriminative stimulus effects of THC exhibit pharmacological specificity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245942
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A refinement of the terpolymer equation and its simple extension to two- and four-component systems (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 2481-2497 
    Details
    ISSN: 0887-624X
    Keywords: chain copolymers ; radical ; ionic ; terpolymers ; tetrapolymers ; multicomponent polymers ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Terpolymer composition estimation with an established equation has been found to give results that vary with the feed monomer ratio substitution pattern used. A new copolymer equation has been derived that overcomes this difficulty to give the same composition results regardless of the order of monomer substitution. The new equation also gives comparable or better agreement with experimentally determined copolymer compositions than obtained by use of the established Alfrey-Goldfinger terpolymer equation. In addition, this new terpolymer equation demonstrates a versatility not shown by the present terpolymer equations in that it can be readily adapted by inspection to enable estimation of copolymer compositions for two- or for four-component polymer systems. It is also readily adaptable for copolymers with more than four components, and may also be valid for composition estimation of these because of the derivation method used, although it has not as yet been possible to test this possibility. © 1996 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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