ISSN:
1420-908X
Keywords:
Cytokines
;
Rheumatoid arthritis
;
Antiinflammatory drugs
;
Substance P
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1β and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients. All patients had high synovial fluid cytokine and substance P levels, and high plasma cytokine levels at the beginning of the study. The treatment with the non steroidal anti inflammatory drugs significantly decreased both plasma and synovial fluid IL-6 and synovial fluid substance P in comparison to placebo, but did not affect IL-1β concentrations. This effect can participate in the therapeutic effect of non steroidal anti inflammatory drugs in rheumatoid arthritis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01837915
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