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  • Electronic Resource  (3)
  • 1990-1994  (2)
  • 1985-1989  (1)
  • Noradrenaline  (1)
  • Optimal stacking sequence  (1)
  • carboxypeptidase P  (1)
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Material
  • Electronic Resource  (3)
Years
  • 1990-1994  (2)
  • 1985-1989  (1)
Year
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  • 1
    Electronic Resource
    Electronic Resource
    Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones (1991)
    Springer
    Pflügers Archiv 418 (1991), S. 592-600 
    Details
    ISSN: 1432-2013
    Keywords: Ca2+ channels ; G protein ; Sympathetic ganglion ; Acetylcholine ; Noradrenaline ; Muscarinic receptors ; α-adrenergic receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of acetylcholine (ACh) and noradrenaline (NA) on voltage-gated ion channels of sympathetic neurones acutely dissociated from rat superior cervical ganglion (SCG) were examined using the whole-cell voltage-clamp technique. Depolarizing voltage steps elicited two types of low- and high-voltage-activated (LVA and HVA) Ca2+ currents. Pressure applications of ACh and NA produced concentration-dependent inhibition of the HVA Ca2+ current without affecting the LVA Ca2+ current. The inhibitory action of ACh on the Ca2+ current was blocked by a muscarinic antagonist, atropine. The action of NA was suppressed by an α 2-adrenergic antagonist, yohimbine, but not by an α 1-adrenergic antagonist, prazosin. Delayed rectifying outward K+ currents and inward rectifying K+ current were not affected by either ACh or NA. Tetrodotoxin-sensitive and -insensitive Na+ currents also remained unaffected under actions of ACh and NA. When recorded with electrode containing guanosine-5′-O-(3-thiotriphosphate) (GTP-γ-S), the inhibitory actions of ACh and NA on Ca2+ currents became irreversible. After treatment of SCG neurones with pertussis toxin, the inhibitory action of ACh on the Ca2+ current was almost completely abolished, whereas the action of NA was only partially reduced. The results suggest that ACh and NA differentially inhibit the HVA Ca2+ current via different G proteins coupling muscarinic and α 2-adrenergic receptors to Ca2+ channels in rat SCG neurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370576
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Identification of proline-specific carboxypeptidase localized to brush border membrane of rat small intestine and its possible role in protein digestion (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 400-406 
    Details
    ISSN: 1573-2568
    Keywords: small intestine ; brush border membrane ; carboxypeptidase P
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A proline-specific carboxypeptidase (carboxypeptidase P, EC 3.4.12.-) was identified and partially characterized in the brush border membrane fraction of rat intestinal enterocytes and shown to be distinct from pancreatic proteases. The carboxypeptidase activity of isolated brush border membranes, with Z-Gly-Pro-Leu as substrate, was 43 nmol/min/mg protein representing a 16-fold purification when compared with mucosal cell homogenates. Activity was maximal in the middle region of the small intestine, and villus cells had twice the activity of crypt cells. Carboxypeptidase activity was maximal at pH 7.0, was stimulated by divalent cations, and was inhibited by metal chelating agents, suggesting that it is a metalloenzyme. The enzyme had the highest activity with synthetic peptides containing proline penultimate to the carboxy terminus. In vivopatterns of hydrolysis and absorption of amino acids from Z-Pro-Trp were examined using an intestinal perfusion technique. These studies indicate that brush border membrane carboxypeptidase may play an important role in the digestion of prolinecontaining peptides and proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536262
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    On the failure indices of quadratic failure criteria for optimal stacking sequence design of laminated plate (1994)
    Springer
    Applied composite materials 1 (1994), S. 81-85 
    Details
    ISSN: 1573-4897
    Keywords: Failure index ; Quadratic failure criteria ; Maximum strength ; Optimal stacking sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The quadratic failure criterion, which is intended to predict fracture, may be used as an object function for optimal stacking sequence design of laminated plate. However, calculations using a symmetric laminated plate demonstrate that Tsai-Wu theory may give incorrect optimum predictions under uniaxial loading.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00567214
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    Paper (German National Licenses)
    Fulltext
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