ISSN:
1573-2568
Keywords:
lower esophageal sphincter pressure
;
cholecystokinin
;
cholestyramine
;
loxiglumide
;
CR1505
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxiglumide, 15 mg/kg/90 min) on LESP in seven healthy subjects. LESP was recorded for 90 min, in 10-min intervals, with the pull-through technique using a four-lumen water-perfused catheter. Oral ingestion of cholestyramine resulted in a significant (P〈0.05) decrease in LESP, starting from 10 min and continuing during the entire experiment (basal LESP: 11.8±2 mm Hg, minimal value reached during cholestyramine: 7.3±1 mm Hg;P〈0.05). Pretreatment with loxiglumide completely antagonized the effect of cholestyramine on LESP. Infusion of loxiglumide without cholestyramine did not affect basal LESP. It is concluded that: (1) cholestyramine significantly reduces LESP; (2) this reduction in LESP does not occur after pretreatment with loxiglumide, indicating that cholestyramine influences LESP through CCK release; and (3) basal LESP is not regulated by CCK.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01296114
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