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  • Electronic Resource  (6)
  • 1990-1994  (1)
  • 1975-1979  (5)
Material
  • Electronic Resource  (6)
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @Cambridge law journal 36 (1977), S. 15-17 
    ISSN: 0008-1973
    Source: Cambridge Journals Digital Archives
    Topics: Law
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @Cambridge law journal 34 (1975), S. 32-34 
    ISSN: 0008-1973
    Source: Cambridge Journals Digital Archives
    Topics: Law
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 480-480 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has been suggested by Tomasi et ai1 that prostaglandin (PG) E2 inhibits the synthesis of PGI2 (prostacyclin) by endo-thelial cells. This conclusion was based mainly on their observation that the inhibition of platelet aggregation produced by a suspension of isolated hepatic cells (described as ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 337-339 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Previous studies of the effects of PGs on platelet aggregation used platelets suspended in citrated plasma (with most of the calcium chelated) or in calcium-free artificial media. The effects of PGEX on several biological systems are influenced by the ionised calcium concentration10'11 and platelet ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 549-551 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Pig aortic endothelial cells, aortic medial smooth muscle cells, and aortic adventitial fibroblasts, were isolated and grown in homogeneous monolayer cultures according to previously described methods7'8. For experiments cells were detached (0.1 % trypsin + 0.025% EDTA; 37 C; 2 min) and suspended ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of neutrophils in the pathogenesis of acute colitis was investigated using a rabbit model. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid in 30% ethanol. Myeloperoxidase activity was measured at various times after induction of colitis as an index of neutrophil infiltration, and this was confirmed by histology. The permeability of the colonie epithelium to [51Cr]EDTA was also measured at various times after induction of colitis. The most marked increase in neutrophil infiltration of the colon occurred during the period 3–6 h after induction of colitis. This was also the period in which the greatest increase in colonie permeability was observed. Pretreatment with a monoclonal antibody (IB-4) directed against the leukocyte adhesion molecule, CD18, markedly suppressed neutrophil infiltration into the colonie tissue after induction of colitis. This pretreatment also significantly reduced the extent of epithelial injury. Administration of IB-4 to rabbits 12 h after induction of colitis resulted in a rapid decline in tissue myeloperoxidase activity. When measured 12 h after IB-4 administration (3 mg/kg), colonie myeloperoxidase activity was reduced by about 80% compared to the control group treated with the vehicle. These results are consistent with the hypothesis that neutrophils contribute significantly to the epithelial dysfunction that characterizes colitis and suggest that antibodies directed against adhesion molecules may represent a novel approach to the treatment of intestinal inflammatory disorders.
    Type of Medium: Electronic Resource
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