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  • Electronic Resource  (3)
  • 1990-1994  (2)
  • 1965-1969  (1)
  • Chiral separation  (2)
  • Propranolol ester derivatives  (2)
  • Accommodation  (1)
Source
Material
  • Electronic Resource  (3)
Years
  • 1990-1994  (2)
  • 1965-1969  (1)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Accommodative behavior of cat pyramidal tract cells investigated with intracellular injection of currents (1968)
    Springer
    Experimental brain research 5 (1968), S. 173-188 
    Details
    ISSN: 1432-1106
    Keywords: Accommodation ; PT cell ; Membrane impedance ; Linearly rising currents ; Current steps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Single glass microelectrodes were inserted into pyramidal tract (PT) cells of cat's cerebral cortex. Accommodative properties of their membranes were investigated by intracellular injection of depolarizing currents. 2. The threshold-latency curve was derived by applying linearly rising currents. When the rising slope of the current was decreased gradually, the threshold intensity first decreased, and then later increased, reaching a certain constant value in the manner of a ceiling. 3. Factors determining this characteristic threshold-latency curve were analyzed by using current steps. A special form of the membrane impedance was thus revealed; the time course of the potential changes induced by current steps can be approximated by the sum of three exponential curves, just as in motoneurones. Threshold-latency curves calculated for a triple exponential model of the membrane fit closely to the actual ones. It implies that the PT cells have no genuine accommodation under normal conditions. 4. Local responses and alterations in the critical depolarization were considered to contribute only minutely to the threshold-latency curve of the PT cell membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238662
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Retention, enantioselectivity and enantiomeric elution order of propranolol and its ester derivatives on an alpha1-acid glycoprotein-bonded column (1992)
    Springer
    Chromatographia 33 (1992), S. 127-132 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Chiral separation ; Alpha 1-acid glycoprotein-bonded column ; Propranolol ; Propranolol ester derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention, enantionselectivity and enantiomeric elution order of racemic propranolol (PP) and its ester derivatives (O-acetyl,-propionyl,-butyrul and-valeryl PP) on an α1-acid glycoprotein (AGP)-bonded column have been investigated by changing eluent composition (eluent pH, buffer concentration, type and content of organic modifier). The retention of these cationic solutes, PP and its ester derivatives, was influenced by eluent pH, ionic strength and organic modifier content. The enantioselectivity was dependent on eluent pH and type of organic modifier. Reversal of the enantiomeric elution order of ester derivatives of PP (O-propionyl-butyryl) and-valeryl PP) occurred around eluent pH 6–7. These results suggst that chiral recognition or binding properties may be altered by the change in eluent composition, espeically eluent pH and type of organic modifier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02275892
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chiral separation of propranolol and its ester derivatives on an ovomucoid-bonded silica: Influence of pH, ionic strength and organic modifier on retention, enantioselectivity and enantiomeric elution order (1990)
    Springer
    Chromatographia 29 (1990), S. 587-592 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ovomucoid-bonded silica ; Chiral separation ; Propranolol ; Propranolol ester derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention, enantioselectivity and enantiomeric elution order of racemic propranolol (PP) and its ester derivatives (O-acetyl,-propyl,-butyl and-valeryl PP) on an ovomucoid-bonded silica column have been investigated with respect to pH, ionic strength and organic modifier. For these cationic solutes, an increase in the organic modifier content and/or a decrease in the pH result in a decreased retention of both enantiomers. Enantioselectivity of the ester derivatives was higher than of underivated PP. The enantiomeric elution order was (S)/(R) for PP and (R)/(S) for the four ester derivatives, when ethanol or 2-propanol was used as the organic modifier. When methanol or acetonitrile was used as the organic modifier, inversion of the enantiomeric elution order was observed for O-valeryl PP with the use of methanol and for PP and O-propyl PP with acetonitrile. These results suggest that at least two chiral binding- or recognitionsites are present in a protein molecule and/or conformational changes occur in the chiral binding- or recognition-site(s) of the protein molecule bonded to a silica matrix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261228
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    Paper (German National Licenses)
    Fulltext
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