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Population kinetics of gentamicin in neonates (1993)

Weber, W. ; Kewitz, G. ; Rost, K. L. ; [et al.]

Springer

European journal of clinical pharmacology 44 (1993), S. S23

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ISSN: 1432-1041

Keywords: Gentamicin ; Neonates ; population kinetics ; prediction of kinetic parameters

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A population kinetic analysis was carried out on sparse plasma gentamicin (GE) concentration data from 469 neonates obtained as part of a routine therapeutic drug monitoring (TDM) programme in the hospital neonatology unit. The best predictors of the kinetic parameters of the monoexponential model, volume of distribution (Vd) and clearance (CL), were the weight (WT) and gestational age (GA). Vd of the neonates was only related to WT, whereas the half-life was only related to the GA. The clinical implications of the findings are that the initial dose per WT administered to premature infants should be larger than that for term infants, because of a larger Vd per unit WT, and the intervals between maintenance doses should extended due to the prolonged half-life. Apart from these general guidelines, specific dose recommendations are also given.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01428387

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Raman investigation of simple and complex oxides of platinum (1991)

Graham, G. W. ; Weber, W. H. ; McBride, J. R. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Journal of Raman Spectroscopy 22 (1991), S. 1-9

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ISSN: 0377-0486

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Raman spectra were obtained from PtO, Pt5O6, Pt3O4, α-PtO2, β-PtO2, MxNayPt3O4 (M = Co, Ni), PtCoO2 and MPt3O6 (M = Mn, Co, Cd). An enumeration of the allowed Raman modes is made for all of these oxides except Pt5O6, for which the structure is unknown. Polarization measurements allow symmetry species assignments to be made for the lines from α-PtO2 and PtCoO2, and a likely assignment of the lines from β-PtO2 is made by analogy with rutile-structured materials with the rutile structure.

Additional Material: 15 Ill.