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  • Electronic Resource  (2)
  • 1990-1994  (2)
  • 42.55.Rz  (1)
  • O6-alkylguanine  (1)
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  • Electronic Resource  (2)
Years
  • 1990-1994  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Determinants of a genotoxic effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human diploid fibroblasts (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 295-298 
    Details
    ISSN: 1432-1440
    Keywords: NNK ; O6-alkylguanine ; DNA-alkyltransferase ; Micronucleus assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The induction of micronuclei was studied in human diploid fibroblasts incubated in the presence of the tobacco-specific nitrosamine NNK. We used four fibroblast strains having a high capacity of 06-alkylguanine DNA alkyltransferase (13.0–23.3 pmol 06-methylguanine repaired per 8 × 106 cells) and four strains that showed no detectable repair capacity. Incubation with NNK doubled the frequency of micronuclei in repair-deficient cells but failed to evoke any effect in the proficient cell strains. Control experiments were performed with the direct methylating agent MNNG and in the presence of inhibitors of either metabolic activation or alkyltransferase. The results showed that the genotoxicity of NNK is dependent on the relationship between its metabolic activation and the constitutive DNA repair. This supports earlier findings that low constitutive levels of 06-alkylguanine DNA alkyltransferase may increase susceptibility to lung cancer after exposure to DNA methylating agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184665
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tunable room-temperature laser action of Cr4+-doped Y3ScxAl5−xO12 (1994)
    Springer
    Applied physics 58 (1994), S. 153-156 
    Details
    ISSN: 1432-0649
    Keywords: 42.55.Rz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new class of tunable room-temperature Cr4+ lasers is presented: Cr4+-doped Y3ScxAl5−xO12 garnets. With increasing scandium content the emission shifts to longer wavelengths due to the weakening of the crystal field. Free running laser wavelengths are 1440, 1498, 1548 and 1584 nm for x = 0, 0.5, 1.0 and 1.5, respectively. Continuous tunability is obtained from 1309 to 1628 nm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01082351
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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