ISSN:
1435-1803
Keywords:
Coronary microcirculation
;
coronary microvascular diameters
;
endothelial impairment
;
myocardial ischemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primarily governing coronary blood flow. Further studies utilizing measurement of segmental coronary microvascular diameters in isolated microvessels and in the beating heart may elucidate the nature of these interactions. Clinical studies may determine whether reversal of endothelial impairment in the diseased coronary microcirculation contributes to autoregulatory vasodilatation, increases resting myocardial perfusion, and increases the threshold for myocardial ischemia during exercise.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00788525
Permalink
