Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (3)
  • 1990-1994  (3)
  • Edema  (2)
  • Calorcoris angustatus  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Edema formation and cellular alterations following spinal cord injury in the rat and their modification with p-chlorophenylalanine (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 604-610 
    Details
    ISSN: 1432-0533
    Keywords: Trauma ; Spinal cord injury ; Edema ; Serotonin ; p-CPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The possibility that serotonin can modify the early pathological sequences occurring in spinal cord trauma was investigated in a rat model. To that end we took advantage of the possibility of influencing serotonin pharmacologically by treating animals with a serotonin synthesis inhibitor, p-chlorophenylalanine (p-CPA) before the production of the injury and compared the results with injured, untreated controls. A unilateral incision was made into the dorsal horn of the lower thoracic cord (about 2.5 mm deep, 4.5 mm long) and the trauma. The injured region from untreated animals showed macroscopically at that time a pronounced swelling and the water content had increased by 3.5% as compared to intact controls. The segments rostral and caudal to the lesion also exhibited a profound increase in water content. Light microscopy revealed a significant expansion of the spinal cord as compared to controls. The swelling was most pronounced in the gray matter on the injured side. Electron microscopy showed distorted neurons, swollen astrocytes and extracellular edema in the gray matter in and around the primary lesion. There was also a sponginess in the surrounding white matter with disruption of myelin, collapsed axons and widened periaxonal spaces. Pretreatment of the rats with p-CPA significantly reduced the swelling of the injured spinal cord and there was no visible expansion. The ipsilateral edema in the central gray matter was considerable less pronounced as compared to that in untreated animals. The increase in water content was less than 1% in these animals. The neuronal and glial cell changes were also markedly reduced in the drugtreated rats. The disruption of myelin and the vacuolation of the gray matter were much less severe. Our results show that p-CPA can markedly modify the edema and the cellular changes occurring in the traumatic spinal injury and indicate that serotonin is somehow involved in the production of the early, and thus important, pathological events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294237
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 145-153 
    Details
    ISSN: 1432-0533
    Keywords: Spinal cord trauma ; Edema ; Myelin basic protein ; Indomethacin ; Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The possibility that prostaglandins participate in the formation of perifocal edema and cell changes following a localized trauma to the spinal cord was investigated in a rat model. A laminectomy was performed in urethane-anesthetized animals at the thoracic T10–11 segment. Using a scalpel blade a unilateral lesion, about 2 mm deep and 5 mm long was made 1 mm to the right of the midline. The deepest part of the injury occupied Rexed's lamina VII of the dorsal horn. Animals were pretreated with the prostaglandin synthesis inhibitor, indomethacin (10 mg/kg, i.p. 30 min prior to trauma). Five hours after the injury the water content was determined and cell changes in and around the primary lesion were examined by light and electron microscopy. Normal and injured rats without indomethacin pretreatment served as controls. Untreated injured rats showed a profound increase of water content in the traumatized T10–11, the rostral (T9) and caudal (T12) segments compared with normal rats. These segments also exhibited marked cell changes in ipsilateral and contralateral dorsal and ventral horns. The gray matter had a spongy appearance and some nerve cells were condensed and distorted. The white matter contained many distorted fibers. Immunostaining for myelin basic protein showed a marked reduction of reaction product in the injured animals compared with normal rats. Ultrastructurally widened extracellular spaces, cytoplasmic vacuolation, swollen and condensed neurons, swollen astrocytes and vesiculation of myelin were frequent findings. Pretreatment of rats with indomethacin significantly reduced the accumulation of water in the traumatized and in the rostral and caudal segments. The structural changes were less pronounced particularly in the cranial and caudal segments. The results indicate that prostaglandins somehow are involved in the pathophysiology of perifocal spinal cord injury and influence both the fluid microenvironment and the early cell changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227761
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Genotypic resistance in sorghum to head bug, Calocoris angustatus Lethiery (1991)
    Springer
    Euphytica 58 (1991), S. 193-200 
    Details
    ISSN: 1573-5060
    Keywords: Calorcoris angustatus ; head bug ; host-plant resistance ; mirid ; Sorghum bicolor ; sorghum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Sorghum head bug, Calocoris angustatus Leth., is an important pest of grain sorghum. We screened nearly 15000 germplasm accessions for resistance to this pest between 1980 and 1990 under natural and headcage conditions. Data were recorded on bug numbers, grain damage (1 = highly resistant the 5 = highly susceptible), and seed germination. Under natural conditions, 34 genotypes suffered moderate levels of grain damage (damage rating (DR) 1.7 to 2.9) compared with a DR of 4.0 to 4.6 in the susceptible controls CSH 1, CSH 5 and CSH 9. IS 17610, IS 17645, IS 21444, IS 19948, IS 25069 and IS 19949 suffered a DR of less than three, and harbored less than 150 bugs/panicle compared with a DR of 4.3 to 4.7, and 248 to 353 bugs/panicle in the susceptible controls CSH 1, CSH 5 and CSH 9 when infested under headcage with 5 pairs of bugs/panicle. IS 18274, IS 20664, IS 20059, IS 25069, and IS 19951 had 150 to 300 bugs/panicle but suffered moderate levels of grain damage (DR less than 3), while the reverse was true in case of IS 8064, IS 19455, IS 19955, IS 20024, IS 20740, IS 23627, IS 2761, and IS 9692. During the 1989 rainy season, IS 14108, IS 17610, IS 17618, IS 17645, IS 19949, IS 19950, IS 19957, IS 20068, IS 25760, IS 27452, IS 27477 and IS 27329 suffered moderate levels of grain damage when infested with 5 and 10 pairs of bugs/panicle, and recorded more than 80% seed germination compared with a DR of 3.9 to 5.0, and seed germination of 15–18% in the susceptible controls CSH 1, CSH 5 and CSH 9. There is a considerable diversity in the genotypes resistant to head bugs, and attempts should be made to transfer the resistance into agronomically acceptable cultivars.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00025250
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...