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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 61 (1990), S. 31-41 
    ISSN: 1432-1246
    Keywords: Interindividual variability ; Static workload ; EMG gaps ; Neck and shoulder complaints ; Electromyography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Standardized and machine-paced work tasks at a packing machine were examined to evaluate interindividual variability of muscle activity patterns. Ten trained female workers, without musculo-skeletal complaints at the time of the recording, performed the work tasks while electromyographic (EMG) recordings were obtained from both upper trapezius muscles. Static muscle activity and periods of between 0.2 and 2 s duration with low muscle activity, EMG gaps, were analysed. Complaints of muscular fatigue, soreness or pain in the neck and shoulders during the last 12 months were recorded. The level of static muscle activity was 1.6 (range 0.4 to 2.5) per cent of maximal voluntary contraction and median number of EMG gaps was 4.8 (range 0.8 to 20) per minute. Workers with previous episodes of complaints (five subjects) had higher levels of static muscle activity and fewer EMG gaps than workers without such episodes (p 〈 0.05, Wilcoxon 2-sample test, one-tailed). Considerable interindividual variability of muscle activity patterns was found in spite of stereotyped work. No causal relations may be inferred from the correlation between the level of trapezius activity and complaints, though it indicates that individual, inexpedient muscle activity patterns may constitute an important risk factor for development of musculo-skeletal complaints.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-5233
    Keywords: Glipizide ; Type 2 diabetes mellitus ; Glucose metabolism ; GLUT 4 ; Glycogen synthase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To examine whether sulphonylureas influence hyperglycaemia-induced glucose disposal and suppression of hepatic glucose production (HGP) in type 2 diabetes mellitus, a 150-min hyperglycaemic (plasma glucose 14 mmol/l) clamp with concomitant somatostatin infusion was used in eight type 2 diabetic patients before and after 6 weeks of glipizide (GZ) therapy. During the clamp a small replacement dose of insulin was given (0.15 mU/kg per min). Isotopically determined glucose-induced glucose uptake was similar before and after GZ administration which led to improved glycaemic control (basal plasma glucose 12.2±1.3 vs 8.9±0.7 mmol/l;P〈0.01). Glucose-induced suppression of HGP was, however, more pronounced during GZ treatment (0.96±0.14 vs 1.44±0.20 mg/kg per min;P〈0.02). Following GZ treatment hyperglycaemia failed to stimulate glycogen synthase activity. Moreover, GZ resulted in a significant increase in the immunoreactive abundance of the insulin-regulatable glucose transport protein (GLUT 4) (P〈0.02). In conclusion, these results suggest that GZ therapy in type 2 diabetic patients enhances hepatic sensitivity to hyperglycaemia, while glucose-induced glucose uptake remains unaffected. In addition, GZ tends to normalize the activity of glycogen synthase and increases the content of GLUT 4 protein in skeletal muscle.
    Type of Medium: Electronic Resource
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