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Increased frequency of micronuclei in lymphocytes of Swedish chimney sweeps (1994)

Holmén, A. ; Karlsson, A. ; Bratt, I. ; [et al.]

Springer

International archives of occupational and environmental health 66 (1994), S. 185-187

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ISSN: 1432-1246

Keywords: Micronucleus test ; Lymphocyte subsets ; Chimney sweeps ; Asbestos ; Benzo[a]pyrene

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Forty-five Swedish chimney sweeps and 49 controls were investigated with micronuclei stimulated by phytohemagglutinin and pokeweed mitogen and by analysis of lymphocyte subgroups and neutrophilic leukocytes. There was a statistically significant effect among sweeps with respect to both micronuclei variables and neutrophilic leukocytes. The effect on lymphocyte micronuclei was most prominent in pokeweed mitogen-stimulated cells, which may imply that the T4 lymphocytes were preferentially damaged by the occupational exposure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00380778

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Separation of enantiomeric amines and acids using chiral ion-pair chromatography on porous graphitic carbon (1992)

Karlsson, A. ; Pettersson, C.

New York, NY [u.a.] : Wiley-Blackwell

Chirality 4 (1992), S. 323-332

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ISSN: 0899-0042

Keywords: chiral separation ; chiral counterion ; ion-pair chromatography ; N-benzyloxycarbonylglycyl-L-proline ; quinine ; indirect detection ; porous graphitic carbon ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The application of porous graphitic carbon as adsorbing phase for direct separation of enantiomeric acids and amines using chiral ion-pair chromatography is described. The enantiomeric amines were separated as diastereomeric ion pairs with N-benzyloxycarbonylglycyl-L-proline, N-benzyloxycarbonylglycylglycyl-L-proline, or captopril as the chiral counterion. High enantioselectivities were obtained for amines having a hydrogen bonding function in the vicinity of the asymmetrical carbon atom. Quinine was the chiral counterion used to separate the enantiomeric acids. The strongly UV-absorbing quinine improved detection of solutes having low UV-absorbing properties, e.g., (R,S)-2-chloropropionic acid, by “indirect detection.” Retention and stereoselectivity of enanticmeric acids were regulated by the quinine concentration and by the addition of carboxylic acids as well as polar modifiers, e.g., methanol and 2-propanol, to the mobile phase. © 1992 Wiley-Liss, Inc.

Additional Material: 7 Ill.