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  • Electronic Resource  (3)
  • 1985-1989  (2)
  • 1970-1974  (1)
  • Fracture healing  (1)
  • Hepatotoxiciy  (1)
  • computer simulation  (1)
Material
  • Electronic Resource  (3)
Years
  • 1985-1989  (2)
  • 1970-1974  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 1 (1973), S. 201-216 
    ISSN: 1573-8744
    Keywords: area analysis ; pharmacokinetic model ; rate constant determination ; biotransformation products ; computer simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The principle of area analysis was used in the development of a metabolic and pharmacokinetic model for an extensively biotransformed drug. Area analysis was also used to determine the rate constants associated with the model. The drug used to exemplify the utility of area analysis in developing such a model was N4-ethoxyacetylsulfamethoxazole. Administration of this drug to the monkey results in three recognizable biotransformation products. Each of the four compounds was administered intravenously to a monkey on separate occasions. Excellent agreement was obtained between the simulated and actual blood levels of the intact drug and its three biotransformation products. Such agreement between the simulated and experimental data reflects the utility of area analysis as the basis for the design of a metabolic and pharmacokinetic model.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 4 (1985), S. 183-188 
    ISSN: 1434-9949
    Keywords: Gold ; Rheumatoid Arthritis ; Juvenile Rheumatoid Arthritis ; Hepatotoxiciy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gold hepatotoxicity is an uncommon but significant clinical problem. Hepatitis was first manifested one day to four weeks after the last dose of gold at a cumulative range of 35 to 2900 mg. An interesting dichotomy was noted between cholestatic and hepatotoxic reactions. Hepatotoxic reactions were associated with other clinical signs of hyper-sensitivity, thus facilitating differential diagnosis from viral hepatitis. Sudden clinical improvement in a patient receiving gold should stimulate evaluation for a hepatotoxic reaction.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 3 (1985), S. 325-330 
    ISSN: 0736-0266
    Keywords: Fracture healing ; Biomechanics ; External fixation ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Fercture site axial rigidity was monitored nonestructively at weekly intervals during healing of tibial osteotomies in adult rabbits. Two groups of 20 rabbits each were treated with external fixators of two different rigidities. Four animals from each group were killed at 3,5,6,7, and 8 weeks to determine the bending moments at failure of the healing fractures. Normal fracture healing was accompanied by characteristic phases in the development of fracture site axial rigidity. From 0 to 3 weeks there was a period of low and approximately constant rigidity, followed by a linear increase during 3 to 5 weeks to an approximately three to four times greater rigidity. The maximum average normalized axial rigidities were reached at 6 weeks and were 57% (high rigidity group) and 77% (low rigidity group) of the untreated contralatreal controls. The Maximum average normalized failure moments occurred at 8 weeks and were 48% (high rigidity) and 44% (low rigidity) of controls. The differences due to fixator rigidity were not statistically significant except for a large increse in failure moments at 3 weeks for the low rigidity group. Axial rigidities were correlated (r2 = 0.74 and 0.53, respectively) with failure moments, but only during the first 6 weeks. The monitoring technique provides a nondestructive means for following the biomechanical progress of fracture healing in in an animal model. The occurrence of the characteristic increase in fracture site axial rigidity at 3 to 5 weeks can also be used to distinguish between normal and abnormal healing.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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