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  • Digitale Medien  (7)
  • 1985-1989  (5)
  • 1965-1969  (2)
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  • Digitale Medien  (7)
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  • 1
    Digitale Medien
    Digitale Medien
    Neue Forschungsergebnisse auf dem Gebiet der Blut- und Serumgruppen (1968)
    Springer
    International journal of legal medicine 62 (1968), S. 173-173 
    Details
    ISSN: 1437-1596
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00587111
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ein Beweis für die Existenz des Hp°-Gens Mutter Hp 1-1, Kind Hp 2-2 (1968)
    Springer
    International journal of legal medicine 63 (1968), S. 111-113 
    Details
    ISSN: 1437-1596
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Summary It was demonstrated on the basis of an incompatible mother-child pair that in the white population, too, Hp° must be supposed to appear. The case was observed among more than 4,000 mother-child pairs which were inconspicuous.
    Notizen: Zusammenfassung Es wird über eine inkompatible Mutter-Kind-Paarung (Mutter Hp 1-1, Kind Hp 2-2) berichtet, wobei normale Typen festgestellt wurden. Eine Kindesvertauschung wurde durch Einbeziehung eventueller für die Vertauschung in Frage kommender Probanden ausgeschlossen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00584061
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  • 3
    Digitale Medien
    Digitale Medien
    Development of the first meiotic prophase stages in human fetal oocytes observed by light and electron microscopy (1987)
    Springer
    Human genetics 〈Berlin〉 77 (1987), S. 223-232 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The development of the first meiotic prophase stages was studied in two series of human female embryos and fetuses aborted for social reasons. The first series (64 embryos or fetuses aborted at 6–24 weeks of gestation) was used mainly to perfect the methods applied to obtain chromosome preparations and synaptonemal complex spreads. The second series (37 embryos or fetuses aborted at 9–24 weeks of gestation) was used to establish the timing and to charcterize the different stages of prophase I. Leptotene-zygotene figures were observed in some embryos at 10 weeks of gestation. Typical zygotene figures were seen at 11–22 weeks. Pachytenes were first observed at 12–13 weeks, and the proportion of these figures was usually lower than 40%. Diplotenes were seen in fetuses with a gestational age of 14 weeks or more. The duration of the process in the human female is thus about 3–4 weeks, a similar period to that described for the male.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00284474
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  • 4
    Digitale Medien
    Digitale Medien
    Nucleolar structures in chromosome and SC preparations from human oocytes at first meiotic prophase (1989)
    Springer
    Human genetics 〈Berlin〉 82 (1989), S. 147-153 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary We describe a comparative study of the behavior of nucleolar structures and their relationship with nucleolar chromosomes and synaptonemal complexes at first meiotic prophase of human oocytes in an attempt to elucidate the nature of this cellular organization and to learn more about maternal nondisjunction. The number of main nucleoli varies along the different stages of prophase I and is usually low. It shows an increase from leptotene to pachytene and a decrease from pachytene to diplotene related to a decrease and an increase of main nucleoli volume, respectively. The methodology employed has enabled us to analyze in detail dark bodies, round bodies, dense bodies, and main nucleoli in chromosome or synaptonemal complex spreads. The relationship between nucleolar chromosomes or synaptonemal complexes and the nucleoli implies the existence, in a very reduced space, of chromosomal regions that contain homologous sequences and that are often unpaired. This situation may facilitate the production of heterologous pairing and chromosomal exchanges between nonhomologous chromosomes and finally result in aneuploidy. THus, the situation explained above together with the differences between the oocyte and spermatocyte NOR cycles could be one of the reasons for the higher incidence of aneuploidies of maternal origin at meiosis I.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00284048
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  • 5
    Digitale Medien
    Digitale Medien
    A qualitative study on vanadate effects in the tetrahydrofolate-dependent formate transfer in vitro and in vivo in mice (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 336 (1987), S. 111-116 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Vanadate ; Formate ; In vivo drug metabolism ; Tetrahydrofolate ; [14C]CO2 Exhalation analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Parenteral administration of sodium vanadate (NaVO3, 22 mg/kg b.w., i.p.) to mice depresses the oxidation rate of [14C]formate to [14C]CO2, as determined by radioactive breath analysis. The heavy metal-induced inhibition is relatively fast in onset, fairly intense (up to 80% inhibition), of short duration (about 2 h) and strongly correlated to the presence of vanadate (in the pentavalent state) in plasma. The [14C]CO2 exhalation rate from [14C]bicarbonate is less affected by vanadate in vivo, thereby suggesting a specific interference of vanadium in the intermediate step of formate oxidation to HCO3 −. In vitro in mouse liver cytosolic fractions vanadate inhibits the enzymatic transfer of formate to tetrahydrofolic acid. The inhibition is accomplished by a vanadate-dependent oxidative degradation of tetrahydrofolate. In contrast, the concentrations of N5-methyltetrahydrofolate, dihydrofolate and folate remain unchanged upon in vitro-exposure to vanadate. The in vitro studies thus might explain the observed inhibition of formate oxidation to carbon dioxide in vivo by a vanadate-evoked depletion of its biological carrier tetrahydrofolic acid. Whether the interference in tetrahydrofolate metabolism also occurs under in vivo conditions, remains to be elucidated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00177760
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  • 6
    Digitale Medien
    Digitale Medien
    The influence of hypotonic treatment on the morphology of meiotic stages I. Prophase of the first meiotic division of male mice, man and Locusta migratoria (1986)
    Springer
    Genetica 69 (1986), S. 19-26 
    Details
    ISSN: 1573-6857
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Male mice were treated with hydroxyurea (HU) to obtain a restricted germ cell population and a sequential analysis of the first meiotic prophase was performed. The results from HU-treated mice were compared with those from untreated mice, human and grasshopper material with and without hypotonic treatment. In hypotonically treated material the three subclasses of diffuse stages were obvious in all species investigated. In material not treated hypotonically the different classes of prophase stages showed a more gradual course, there was a tendency towards less spreading of the bivalents and no pronounced diffuse substages could be found. The first desynaptic stage in this material could be recognized in most cases as wellspread classical ‘pachytene’ like bivalents with a pronounced double-threaded structure. The more advanced desynaptic stage in untreated material resembled the diffuse stage as found in plant meiosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00122930
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  • 7
    Digitale Medien
    Digitale Medien
    The influence of hypotonic treatment on the morphology of meiotic stages II. Prophase of the first meiotic division of female mice up to dictyotene (1986)
    Springer
    Genetica 70 (1986), S. 161-165 
    Details
    ISSN: 1573-6857
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Various investigations of prophase of the first meiotic division of female mice showed different results with respect to the appearance of those stages during ovarian development. It was not clear up to now whether in oocytes, in addition to the dictyotene stage, there exists a diffuse diplotene stage as can be found during male meiosis. In this study the morphology of meiotic prophase stages was compared in preparations of oocytes with and without hypotonic pretreatment. There appears to be a strong effect of hypotonic treatment on the morphology of different meiotic prophase stages and there is a striking resemblance with meiotic stages from male material which was treated similarly. From the results of hypotonically untreated ovarian material it was obvious that early desynaptic stages could be confused with pachytene. In addition, it was demonstrated that there exists a diffuse (diplotene) stage with a duration of approximately 3 days before dictyotene stage. The possible function of the diffuse stage is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00122182
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