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  • Electronic Resource  (3)
  • 1985-1989  (1)
  • 1965-1969  (2)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 25 (1988), S. 296-306 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Release of cardiac histamine by immunologic and pharmacologic stimuli is known to provoke ventricular arrhythmias. Augmented histamine efflux from ischemic myocardium has been proposed but remains controversial. The purpose of this study was to determine whether cardiac histamine efflux is precipitated by coronary artery occlusion and if so, whether histamine efflux is associated with the development of early ischemic ventricular arrhythmias. The left anterior descending coronary artery was occluded while recording a continuous electrocardiogram and coronary sinus blood was sampled frequently during the first 30 min of coronary artery occlusion in pentobarbital-anesthetized, openchest dogs. Coronary sinus histamine concentration rose from a mean baseline of 0.06±0.10 ng/ml (±SD) before coronary artery occlusion to a mean peak of 0.61±0.40 ng/ml after coronary artery occlusion (p〈0.0001;n=14). The median peak coronary sinus histamine concentration was significantly greater in dogs that suffered ventricular fibrillation after coronary artery occlusion (n=4) than in those that did not (n=10) (0.86 ng/ml vs. 0.37 ng/ml;p=0.05). The area under the coronary sinus histamine concentration-vs.-time curve (“total cardiac histamine efflux”) correlated directly with the total number of ventricular premature contractions during the first 30 min after coronary artery occlusion (r=0.81;p〈0.005;n=10), and with infarct size (r=0.91;p〈0.01;n=6). Thus, during acute myocardial ischemia, the coronary sinus histamine concentration increases simultaneously with the development of early ischemic ventricular arrhythmias and in proportion to their severity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 23 (1967), S. 66-67 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto È stato dimostrato che l'istamina ha un effetto sulle cellule del nodo seno-atriale del cuore di coniglio. Tale effetto consiste in un marcato aumento della velocità di depolarizzazione del potenziale «pacemaker», cui consegue un effetto cronotropo positivo.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 6 (1966), S. 409-419 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A study on the tightening characteristics of bolt-nut-washer assemblies was undertaken after a preliminary literature survey showed different opinions to exist on the effect of several commonly encountered factors on the torque-tension relationship. The test program included tightening bolts up to the yield point under a planned series of combination of factors, and recording nut-tightening torque, bolt torque and tension. The main factors tested were: (a) Plating of the mating surfaces of bolt, nut and washer (b) Lubrication of the interfaces. Among the subsidiary factors considered were the hardness and yield stress of the materials and the class of fit of the threads. The tests were planned and analyzed with statistical techniques in order to obtain estimates of the effects of each factor and the more important interactions (singled out of the total number in a series of pilot tests) as well as of the errors to be considered for the tests of significance. The analysis was carried out with mathematical and graphical methods giving accurate results in an easily understandable form from a reasonably small number of experimental data. The isolation of the main effects and interactions was achieved with no loss of general applicability of the results, taking advantage of the peculiar properties of the factorial experimental design adopted. A comparison between the torque wrench and the turn-of-nut method of bolt-tightening is made in terms of closeness of bolt tension control. A simple bolt-testing machine was built for the tests. A motor-driven wrench with a strain-gage bridge measuring the input torque tightened the nut at low speed while a two-component strain-gage transducer measured bolt torque and tension. Provision was also made for measuring the angle of rotation of the nut and the torsion of the bolt's shank.
    Type of Medium: Electronic Resource
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