ISSN:
1432-1106
Keywords:
Hippocampal pyramidal cells
;
Phorbol esters
;
Synaptic transmission
;
Plasticity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary (1) The effect of active and inactive phorbol esters on synaptic transmission and on membrane properties of CA1 pyramidal cells in hippocampus have been analyzed by intracellular recording. (2) 4β-phorbol-12,13 dibutyrate (βPDBu), but not the α-isomer, increased the firing probability, reduced the spike latency and enhanced the EPSP amplitude in response to synaptic activation. The effect was similar to the changes seen in long term potentiation. After αPDBu addition it was possible to elicit further enhancement by tetanization, but not after βPDBu administration. (3) A slowly developing hyperpolarization was seen after active phorbol ester application without apparent changes in the soma input resistance. (4) Active phorbol esters reduced the slow afterhyperpolarization (AHP) in these cells without affecting the intermediate AHP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00248751
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