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  • Electronic Resource  (3)
  • 1985-1989  (3)
  • 1915-1919
  • 1910-1914
  • Computed tomography  (2)
  • Aging  (1)
  • Ampullary/pancreatic cancer  (1)
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  • Electronic Resource  (3)
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  • 1
    ISSN: 1432-1920
    Keywords: Cerebral blood flow ; Computed tomography ; Partition coefficients ; Xenon contrast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Methods are described for non-invasive, computer-assisted serial scanning throghout the human brain during eight minutes of inhalation of 27%–30% Xenon gas in order to measure local cerebral blood flow (LCBF). Optimized Xenonenhanced computed tomography (XeCT) was achieved by 5-second scanning at one-minute intervals utilizing a state-of-the-art CT scanner and rapid delivery of Xenon gas via a face mask. Values for local brain-blood partition coefficients (Lλ) measured in vivo were utilized to calculate LCBF values. Previous methods assumed Lλ values to be normal, introducing the risk of systematic errors, because Lλ values differ throughout normal brain and may be altered by disease. Color-coded maps of Lλ and LCBF values were formatted directly onto CT images for exact correlation of function with anatomic and pathologic observations (spatial resolution: 26.5 cubic mm). Results were compared among eight normal volunteers, aged between 50 and 88 years. Mean cortical gray matter blood flow was 46.3±7.7, for subcortical gray matter was 50.3±13.2 and for white matter was 18.8±3.2. Modern CT scanners provide stability, improved signal to noise ratio and minimal radiation scatter. Combining these advantages with rapid Xenon saturation of the blood provides correlations of Lλ and LCBF with images of normal and abnormal brain in a safe, useful and non-invasive manner.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Cerebral blood flow ; Partition coefficient ; Computed tomography ; Stable xenon ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Results of measurements of LCBF and Lλ values utilizing optimal CT-CBF methods under resting conditions are reported among thirty-two neurologically normal volunteers aged between 20 and 88 years. Measurements were made during inhalation of 26–30% stable xenon gas for 8 min and serial scanning utilizing a state-of the-art CT scanner with both eyes closed and ears unplugged. LCBF values for cortical gray matter were lowest in occipital cortex and highest in frontal cortex. Gray matter flow values were also high in subcortical structures with highest values measured in the thalamus. For white matter, highest flow values were measured in the internal capsule. Changes in LCBF and Lλ values were analyzed with respect to advancing age. Significant age-related declines in LCBF values were observed in occipital cortex and frontal white matter. Significant age-related increases in Lλ values were measured in frontal and temporal cortex, caudate nucleus and thalamus. Possible explanations are offered for these age-related increases in Lλ values for gray matter, such as accumulation of lipofuscin in neurons and relative compacting of gray matter with advancing age. The latter increases the numbers of nerve cells sampled per volume of gray matter measured.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 365 (1985), S. 169-178 
    ISSN: 1435-2451
    Keywords: Ampullary/pancreatic cancer ; Staging ; TNM ; Therapy ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1974 bis 1982 wurden an der Chirurgischen Universitätsklinik Münster 607 Patienten mit Erkrankungen des Pankreas behandelt, von denen 256 an einem Pankreas- und 42 an einem Papillencarcinom erkrankt waren. Alle wurden nach einem dort eigens entwickelten TNM-System für das Pankreascarcinom eingeteilt. Es ergab sich bei den durchgeführten kurativen Resektionen (n = 73), die für die das Papillencarcinom einen Anteil von 78,6% und für das Pankreascarcinom von 15,6% an den Gesamtoperationen hatten, ein deutliches Überwiegen der frühen Stadien für ersteres (T1N0M0/T2N0M0 〉 60%), der späteren Stadien für letzteres (T1N0M0/T2N0M0 = 25%). Die Fernmetastasenhäufigkeit bezogen auf alle Patienten unterschied sich mit 9,5% bzw. 43,4% ebenfalls signifikant (p 〈 0,05). Bei einem niedrigen Median der Überlebenszeiten für die palliativen Eingriffe ergab sich für die Whipple-OP ein Median von 40,3 Monaten, für die totale Pankreatektomie von 28,0 Monaten. Für das Stadium T1N0M0/T2N0M0 war der Median 〉 63 Monate.
    Notes: Summary From 1974 to 1982 607 patients with diseases of the pancreas were treated at the Surgical University Clinic of Münster/West Germany. 256 of those suffered from pancreatic and 42 from ampullary cancer. All patients were grouped according to a TNM-System for pancreatic cancer developed for that particular purpose. Of the curative resections performed (n = 73) with a resection rate of 78.6% for ampullary and 15.6% for pancreatic cancer, a distinct preponderance of early stages (T1N0M0/T2N0M0 〉 60%) was noticed for the first, of late stages for the latter (T1N0M0/T2N0M0 = 25%). The frequencies of distant metastases for all operations also differed significantly, being 9.5% respectively 43.4% at the time of operation (p 〈 0.05). At the low mean survival time for palliative operations an mean survival time of 40.3 months for the Whipple operation was evaluated, of 28.0 months for total pancreatectomy. At the stage T1N0M0/T2N0M0 the mean survival time was 〉 63 months.
    Type of Medium: Electronic Resource
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