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  • Electronic Resource  (4)
  • 1985-1989  (4)
  • Human epidermal growth factor (hEGF)  (2)
  • 5-trifluoromethyluracil  (1)
  • Dynamical systems  (1)
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  • Electronic Resource  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of 5-fluorouracil with sodium poly-α,L-glutamate (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 682-685 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluorouracial ; sodium poly-α ; L-glutamate ; interaction ; viscosity ; 5-trifluoromethyluracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and its correlations in terms of chemical structure and the potentiactive drug activity. The interaction of 5-fluorouracil (5-fluorouracil is used as an anticancer drug) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on the polymer were calculated. It is very interesting that the value ofΔH0 of the binding of 5-fluorouracil with sodium poly-α,L-glutamate is smaller than that of 5-trifluoromethyluracil (although 5-trifluoromethyluracil is not used as an anticancer drug, the compound has a similar structure to 5-fluorouracil).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419893
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Painlevé resonances versus Kowalevski exponents: Some exact results on singularity structure and integrability of dynamical systems (1987)
    Springer
    Acta applicandae mathematicae 8 (1987), S. 75-103 
    Details
    ISSN: 1572-9036
    Keywords: 70D ; 70H ; Dynamical systems ; integrability ; singularity analysis ; monodromy properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper we present a review of results on the integrability of dynamical systems and its detection. Three different approaches are examined. The first introduces the Kowalevski exponents as related to the singularity structure of some weighted homogeneous differential systems. It is proved that whenever these exponents are irrational or complex, the system cannot be integrable. The second approach is known as the ‘weak Painlevé’ criterion. No (precise) general theorem can be given in this case. However, in the vast majority of cases, irrational or complex Painlevé resonances (which can be different from the Kowalevski exponents in some cases) are indications of nonintegrability. Finally, the method of Ziglin is presented, along with an extension. Ziglin's theorem deals with the branching of the solutions and uses nonlocal information obtained through the monodromy properties around solutions of a special type in order to establish the necessary conditions for integrability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00046688
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    HPLC analysis of human epidermal growth factor using immunoaffinity precolumn. I. Optimization of immunoaffinity column (1989)
    Springer
    Chromatographia 27 (1989), S. 569-573 
    Details
    ISSN: 1612-1112
    Keywords: Immunoaffinity chromatography ; Human epidermal growth factor (hEGF) ; Immobilization of antibody ; Pore size of diol silica ; Optimum coupling conditions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The preparation of support-coupled antibodies for high-performance immunoaffinity chromatography has been demonstrated. Diol silica had the least non-specific adsorption of all supports investigated. The optimum activation conditions for diol silica with 1,1′-carbonyl-diimidazole and the optimum coupling conditions for anti-human epidermal growth factor antibody as a function of salt concentration, pH and ligand concentration were selected. The pore size of the diol silica was an important factor in achieving good results. Diol silica with 500Å pore size had high loading capacity against the antigen. The use of F(ab′)2 or Fab as a ligand showed almost the same chromatographic characteristics as IgG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258980
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    HPLC analysis of human epidermal growth factor using immunoaffinity precolumn. II. Determination of hEGFs in biological fluids (1989)
    Springer
    Chromatographia 27 (1989), S. 574-580 
    Details
    ISSN: 1612-1112
    Keywords: Immunoaffinity chromatography ; Human epidermal growth factor (hEGF) ; Degradation products ; Immunoaffinity precolumn ; HPLC column-switching system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A high-performance liquid-chromatographic, column-switching system for automated sample pre-treatment and determination of human epidermal growth factor and its degradation products (hEGFs) is described. The system consists of an immunoaffinity precolumn (4.0×10mm) packed with diol silica immobilized with antibody against hEGF and an analytical ODS column (4.6×250mm). Samples such as cultured media ofE. coli, human urine, milk, seminal fluid and saliva can be directly injected on the immunoaffinity precolumn and the analytes of interest are trapped by the immobilized anti-hEGF antibody. After washing this precolumn with aqueous solvents, the analytes are desorbed with an aqueous solution of low pH and transferred to the analytical column to allow their separation in reversed phase mode. The recoveries of hEGFs spiked in these biological fluids were over 98%. The detection limit was 1 ng for a 1ml sample injection. This method was applied for the determination of hEGF levels in cultured media ofE. coli and biological fluids. Degradation of hEGF in human serum and urine was also examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258981
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    Paper (German National Licenses)
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