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  • Electronic Resource  (2)
  • 1985-1989  (2)
  • Antiepileptics  (1)
  • Cellulose phosphate  (1)
  • Polymer and Materials Science
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  • Electronic Resource  (2)
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    Testing of prototype antiepileptics in hippocampal slices (1986)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 332 (1986), S. 89-92 
    Details
    ISSN: 1432-1912
    Keywords: Hippocampus ; Antiepileptics ; Penicillin ; Low Ca2+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of six prototype anticonvulsant drugs, phenytoin, carbamazepine, midazolam, phenobarbital, ethosuximide and sodium valproate, were evaluated in two different experimental models of epileptiform activity using the in vitro slice preparation from the rat hippocampus. The relative potencies of the agents were determined: a) in the complete absence of synaptic transmission by recording spontaneous burst firing from the CA 1 pyramidal cell layer in a low calcium high magnesium solution and b) during blocked synaptic inhibition by observing the activity of each drug upon orthodromically evoked population spikes in penicillin containing medium. The rank order of potencies was a) in low Ca2+: carbamazepine, phenytoin, midazolam, phenobarbital, valproate, ethosuximide; b) in penicillin containing medium: midazolam, phenobarbital, carbamazepine, phenytoin, valproate, ethosuximide. These observations illustrate that the use of multiple paradigms is warranted when examining the mechanisms of action of new anticonvulsants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00633203
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Idiopathic hypercalciuria (1985)
    Springer
    Urological research 13 (1985), S. 271-275 
    Details
    ISSN: 1434-0879
    Keywords: Hypercalciuria ; Urate ; Diet ; Bendrofluazide ; Cellulose phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 24 h urine compositions of male stone formers with idiopathic hypercalciuria prior to treatment were compared with those of male general practitioners without urolithiasis. Urinary urate was slightly higher in the stone formers than in the normals but this was not statistically significant. Furthermore, when results were corrected for the higher creatinine excretions of the stone formers then the reverse was true and statistically significant. All subjects with urinary urate over 7.0 mmol/24h were separately studied. In these groups the normals had higher urate and creatinine excretions than the stone formers but when results were corrected for creatinine the difference in the urate excretions disappeared. In long term follow up studies urinary calcium was lowered by diet and more so by diet supplemented with either Bendrofluazide or cellulose phosphate. Each drug raised urinary oxalate slightly and this was statistically significant, while both drugs together caused an even bigger rise in oxalate excretion. An unexpected finding was a rise in urinary urate with cellulose phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262655
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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