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  • Electronic Resource  (3)
  • 1985-1989  (3)
  • Ulcusblutung  (2)
  • Arecoline  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of muscarinic agonists (1987)
    Springer
    Psychopharmacology 93 (1987), S. 139-145 
    Details
    ISSN: 1432-2072
    Keywords: Arecoline ; Pilocarpine ; Oxotremorine ; Acetylcholine ; Muscarinic agonist ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a two-lever, food-reinforced drug-discrimination paradigm separate groups of rats were trained to discriminate either arecoline, pilocarpine or oxotremorine from saline. The discriminative cues of all three agonists were potently blocked by scopolamine, but only by 30–60 fold higher doses of methylscopolamine. The three agonists all suppressed overall response rate. These rate-suppressant effects were not blocked by scopolamine in doses which blocked the discriminative cues. In generalization tests, arecoline elicited selection of the drug-appropriate lever in all groups of trained animals. Pilocarpine was discriminated as drug by all pilocarpine-trained animals and by a majority of oxotremorine-trained animals, but was not significantly discriminated by the arecoline-trained group. Oxotremorine was discriminated by all oxotremorine-trained animals but only by some pilocarpine-trained animals, and was not significantly discriminated by the arecoline-trained group. Morphine, haloperidol, chlordiazepoxide, pentobarbital and nicotine were not generalized to any of the training drugs. The discriminative stimuli produced by the training drugs are therefore specific and exhibit properties indicative of an origin at central muscarinic receptors but may not be identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179923
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    332. Das blutende gastroduodenal-Uleus — herausforderung für endoskopie und chirurgie (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 943-944 
    Details
    ISSN: 1435-2451
    Keywords: Bleeding peptic ulcer ; Recurrent hemorrhage ; Emergency endoscopy ; Ulcusblutung ; Rezidivblutung ; Notfallendoskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch ein aggressiveres endoskopisch-chirurgisches Therapieschema (endoskopische Blutstillung unabhängig vom Forrest-Stadium, F Ia: Auch nach erfolgreicher Unterspritzung OP innerhalb 6 h, F Ib, II: Kontroll-Endoskopie und evtl. nochmalige Unterspritzung) konnten die Ergebnisse -signifikant verbessert werden: Senkung der Re-Blutungsrate von 35% auf 16% (P〈0,05), der Notfall-OP-Rate wegen Re-Blutung von 66% auf 28% (P 〈 0,05), Senkung der Letalität von 14,3% auf 6,3%.
    Notes: Summary Using a new therapeutic regimen for bleeding peptic ulcers, the results improved significantly: endoscopic hemostasis regardless of the Forrest stage, F I a: early operation within 6 h, even if the primary endoscopic hemostasis was successful; F I b, 11: second endoscopy within 24 h and repeat hemostasis, if necessary. The rate of rebleeding was reduced from 35% to 16% (sP〈 0.05), the rate of emergency operations due to rebleeding from 66% to 28% (P〈0.05), and mortality decreased from 14.3% to 6.3%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298117
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    371. Das blutende Gastroduodenalulcus — Enscheidungsfindung und Therapieplanung (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 869-870 
    Details
    ISSN: 1435-2451
    Keywords: Medical decision making ; Bleeding peptic ulcer ; Recurrent haemorrhage ; Emergency endoscopy ; Entscheidungsfindung ; Ulcusblutung ; Rezidivblutung ; Notfallendoskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Hauptproblem in der Therapie des blutenden Ulcus ist die Rezidiv-Blutung nach konservativer oder endoskopischer Blutstillung. Die dann erforderliche Not-OP hat eine hohe Letalität (16%) gegenüber der elektiven OP (7%). Neue Therapie-Richtlinien: Endoskopische Blutstillung in jedem Blutungsstadium. Forrest la: Frühoperation. Forrest I b, II: Kontrollendoskopie nach 24 h. Die wiederholte endoskopische Kontrolle und Blutstillung führt vermehrt zu einer elektiven und selektiven Chirurgie mit einer Abnahme der postoperativen Komplikationen.
    Notes: Summary The main problem in therapy of bleeding peptic ulcer is recurrent haemorrhage after conservative or endoscopic haemostasis. Mortality of emergency operations due to rebleeding was more than twice as high (16%) as mortality of elective operations (7%). New regimen: Endoscopic haemostasis regardless of Forrest stage. Forrest I a: Early operation. Forrest I b, 11: Second endoscopy after 24 h. Repeated endoscopic treatment leads to more elective and selective surgery with decrease of postoperative complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274691
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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