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Food antibodies, intestinal permeability and HLA status in IgA deficient blood donors identified by a new rapid screening test (1986)

GILLON, J. ; BARCLAY, G. R. ; YAP, P. L. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical & experimental allergy 16 (1986), S. 0

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ISSN: 1365-2222

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract. Circulating food antibodies, intestinal permeability and HLA status were studied in twelve blood donors previously identified as being selectively IgA deficient from screening 10 000 donations by means of a latex agglutination inhibition test, and confirmed by laser nephelometry. Assessment of intestinal function also included clinical history and standard laboratory tests. The donors proved to be healthy with no evidence of autoimmune disease or allergy. Nine donors (75%) had precipitins to food antigens. None had increased intestinal permeability as measured by the cellobiose/mannitol absorption test. HLA-A, B and DR antigen distribution was normal. IgG sub-class distribution was normal with the exception of an IgG2 level slightly below normal in one donor (0·9 g/1). An unexpected finding was a return of IgA levels to normal in four donors (33%) within 6 months.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2222.1986.tb01997.x

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Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens (1988)

Beck, Stephan ; Barrell, Barclay G.

[s.l.] : Nature Publishing Group

Nature 331 (1988), S. 269-272

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] MHC class-I a chains are highly polymorphic and are found associated non-covalently with β2-m. They are encoded by eight exons separated by seven introns and show a very conserved Fig. 1 Physical map of HCMV strain AD169.The linear double-stranded DNA genome of HCMV consists of a long ...