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  • Electronic Resource  (2)
  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Co-existence of two aneuploid stemlines in benign adenomas (1989)
    Springer
    Virchows Archiv 415 (1989), S. 175-180 
    Details
    ISSN: 1432-2307
    Keywords: Flow cytometry ; Adrenal neoplasms ; Parathyroid neoplasms ; Pancreatic neoplasms ; DNA content ; Multiploidy ; Stemline heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline heterogeneity and large DNA indices up to 2.8 none of the adenomas recurred or gave rise to metastases after a simple excision during the follow-up of 8, 10 and 11 years. Two adenomas were hormonally active. Marked cellular atypia and frequent mitoses were seen in 1 of the adenomas but the other 2 tumours had little atypia. The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00784356
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  • 2
    Electronic Resource
    Electronic Resource
    18F-fluorodeoxyglucose imaging in preoperative diagnosis of thyroid malignancy (1988)
    Springer
    European journal of nuclear medicine 13 (1988), S. 502-506 
    Details
    ISSN: 1619-7089
    Keywords: Thyroid neoplasms ; Thyroid imaging ; Fluorodeoxyglucose ; Flow cytometry ; DNA aneuploidy ; Differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fourteen human thyroid tumors were studied with 18F-fluorodeoxyglucose (FDG) imaging. The proliferative activity and DNA ploidy of the tumors was assessed by DNA flow cytometry. FDG accumulated in a Hürthle cell carcinoma, an anaplastic carcinoma and a thyroid lymphoma, but only slightly or not at all in the three papillary carcinomas studied. Three of the eight benign tumors also accumulated FDG, but two of these were selected for imaging because of a large number of proliferating cells in DNA flow cytometry. Two carcinomas with increased nuclear DNA content retained FDG, but a histologically benign follicular adenoma with DNA aneuploidy did not. We conclude that in addition to malignant thyroid tumors, histologically benign tumors may also accumulate FDG, and therefore the value of FDG scanning in the preoperative diagnosis of thyroid malignancy is limited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256624
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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