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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical reaction of alpha1 antitrypsin during the substitution therapy of patients with homozygote PI-ZZ defizit (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 328-335 
    Details
    ISSN: 1432-1440
    Keywords: Alpha1 antitrypsin substitution ; Protease inhibition ; Mucosa inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The homozygote deficit of alpha1 antitrypsin (alpha1 PI-ZZ) in patients frequently results in a premature development of emphysema in the lung due to incomplete protection against proteases. An active inhibitor substitution appears to be useful. The presented study proves the biological effect of alpha1 antitrypsin infused into 8 patients. The results were an activity increase of leukocyte elastase and trypsin inhibition in serum as well as doubling of alpha1 antitrypsin in sputum. This therapeutical conception (with a dose of 60 mg/kg body weight/week) results in an efficient protection. Inhibitors specific for mucosa are not influenced. An improvement of lung function during 6 weeks of intravenous therapy was not achieved. The progressive destruction of lung parenchyma can be probably prevented, however.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741387
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine generation by bacteria in sputum of patients with chronic obstructive airway disease (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 92-95 
    Details
    ISSN: 1432-1440
    Keywords: Histamine formation ; Bacteria ; COAD ; Sputum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous investigations have demonstrated high histamine concentrations in the sputum of patients with chronic obstructive airway disease (COAD). A possible histamine generation by bacteria has been discussed. In the present work, histamine concentrations in native and incubated sputum of patients with COAD were determined. Histamine was assayed fluorimetrically after separation by HPLC. Histamine concentration in native sputum amounted to 10–1140 ng/ml. After 72 h incubation at 37° C 100–20700 ng/ml histamine was detected. A mean 26-fold increase in histamine content was observed. Heating of the sputum almost completely prevented the rise in histamine concentration during incubation. The same effect was achieved by adding an antibiotic to the sputum before incubation. Histamine content in sputum of patients with COAD decreased considerably after therapy with the antibiotic doxycycline. Histamine formation by bacteria may account considerably for the histamine concentration in sputum of patients with COAD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01774221
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Leberfunktion von Patienten mit arterieller Hypoxämie bei chronisch obstruktiver Atemwegserkrankung und der Einfluß der nasalen Sauerstoffinsufflation (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 833-838 
    Details
    ISSN: 1432-1440
    Keywords: Chronic obstructive airway disease ; Arterial hypoxemia ; Liver function ; Galactose elimination capacity ; Indocyaninegreen clearance ; Oxygen therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients suffering from chronic obstructive airway disease often have arterial hypoxemia, which is more or less severe. If hypoxemia deteriorates the function of the liver is still unknown. The aim of this study was to determine, if a mostly oxygen dependent process of liver metabolism (galactose elimination capacity) is disturbed and if it can be increased by oxygen insufflation. Under the same conditions an oxygen independent process (indocyaninegreen clearance) should not be influenced. Our results show, that galactose elimination capacity under room air was pathologic and can be increased significantly by oxygen breathing. No change of indocyaninegreen clearance was seen under the same conditions. After termination of oxygen therapy the galactose elimination capacity was as bad as before oxygen breathing. Dysfunctions of the liver, which are caused by hypoxemia, can be positively influenced by oxygen, but only for the duration of oxygen insufflation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725200
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Alpha1-antitrypsin gene polymorphism related to respiratory system disease (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 538-541 
    Details
    ISSN: 1432-1440
    Keywords: Alpha1-antitrypsin gene ; DNA polymorphism ; Chronic obstructive airway disease (COAD)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Restriction fragment length polymorphism (RFLP) in the alpha1-antitrypsin gene region was studied in relation to chronic obstructive airway disease (COAD) and pneumoconiosis. Genomic DNA of 122 studied subjects was digested with Hind III restriction endonuclease and hybridized with the alpha1-antitrypsin gene probe. In eight patients with COAD an unusual 10-kb restriction fragment was found hybridizing with the probe. Three of 70 patients were homozygotes for this variant allele and 5 were heterozygotes, showing the presence of two fragments, 2.7 kb and 10 kb. The presence of 10-kb restriction fragment seems to be related to the early development of COAD in studied subjects and therefore might be used as a genetic marker of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727618
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  • 5
    Electronic Resource
    Electronic Resource
    The role of vagus nerve on histamine- and acetylcholine-induced bronchoconstriction (experiments on cats) (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 29-34 
    Details
    ISSN: 1433-8580
    Keywords: Bronchoconstriction ; Direct action on bronchial muscle ; Histamine ; Acetylcholine ; Vagotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During administration of highly concentrated acetyclcholine and histamine aerosol (20–40 min), different effects on tidal volume, respiratory rate, and bronchial tone could be demonstrated. Inhalation after vagotomy neither showed changes in respiratory rate nor in tidal volume. These results point out the importance of the nervus vagus in case of bronchoconstriction caused by mediators. It is discussed to which degree vagus activity is required for the direct effect of different mediators in living animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851831
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Cell instability in basophil leukocytes of patients with chronic obstructive airway disease (1985)
    Springer
    Research in experimental medicine 185 (1985), S. 415-423 
    Details
    ISSN: 1433-8580
    Keywords: Histamine release ; Basophilic leukocytes ; Hypo-osmolarity ; Age dependency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histamine release from basophils induced by hypo-osmolarity was investigated in 75 healthy persons and in 43 patients with chronic obstructive airway disease. Leukocyte suspensions were diluted with destilled water in cell/water ratio volumen of 1:1, 1:3, and 1:7. Basophils, sequentially treated with increasing amounts of water, show an activation of the release process. A statistically significant age-dependent hypo-osmolar histamine liberation could be demonstrated. Furthermore, a significant higher cell stability was found for the group of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851922
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    Paper (German National Licenses)
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