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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistology and aetiology of histiocytic necrotizing lymphadenitis. Report of three instructive cases (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 7 (1983), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Three cases of histiocytic necrotizing lymphadenitis are reported. Two patients came from Vietnam and the third from Greece. In all cases there was infection with Yersinia enterocolitica of serogroup 9 or 3. Cervical lymph nodes were examined. Histologically, the characteristic necrosis developed in large foci of so-called T-associated plasma cells. Immunological analysis showed that these cells have characteristic markers of helper/inducer T cells, but do not express sheep erythrocyte receptors. The T-associated plasma cells perished by pyknosis and were then phagocytosed and digested by macrophages, which were present in large numbers. The necrotic areas were exclusively located in hyperplastic T regions. The B-cell system did not play a role in the reaction. T-associated plasma cells have been renamed ‘plasmacytoid T cells’ because they contain abundant rough endo-plasmic reticulum (‘plasmacytoid’) and show immunological features of T cells. It appears likely that plasmacytoid T cells are the counterparts of plasma cells of the B-cell system that secrete lymphokines instead of immunoglobulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1983.tb02299.x
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  • 2
    Electronic Resource
    Electronic Resource
    Concordance of the Kiel and Lukes-Collins classifications of non-Hodgkin's lymphomas (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 7 (1983), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Kiel and Lukes-Collins classifications of non-Hodgkin's lymphomas are the only classifications based on immunological concepts. Their cytological types have been confirmed by numerous immunological studies as B- and T-cell types and have been related to clinicc-pathological entities. In this presentation, the cytological types of the two classifications are compared. Eleven of the 13 major types of the Lukes-Collins classification are essentially identical with the Kiel counterparts, though the terminology differs in four of the 11 types. In the two types in which discordance occurs, the relationship between the types of the two classifications are clarified. As a result, the two classifications are placed into effective alignment for understanding and translating terminological differences. Both classifications represent sound bases for morphological diagnoses and also for relating the results of the broad range of current and future immunological studies to morphology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1983.tb02267.x
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  • 3
    Electronic Resource
    Electronic Resource
    Primary malignant lymphomas localized in salivary glands (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Biopsies from 25 patients with primary malignant lymphoma in the salivary region were investigated morphologically and the clinical findings were analysed. Cases showing myoepithelial sialadenitis or Sjögren's syndrome were not included. The tumour was localized in the parotid region in 21 cases and to the submandibular region in four cases. Non-Hodgkin's lymphoma was diagnosed on 21 biopsies and Hodgkin's disease on four: all patients were of stages I or II. The most frequent type of malignant lymphoma was the centroblastic-centrocytic type; sclerosis was found in all but one of these 15 cases. Polymorphic immunocytoma was diagnosed in two cases, centroblastic lymphoma in two cases and immunoblastic lymphoma in two cases. In eight patients, the lymphomas definitely originated in intraglandular lymph nodes; in 10 other patients, the lymphomas might have developed in intraglandular lymph nodes. It was not possible to determine the origin of the lymphoma in the other seven cases. The prognosis was relatively favourable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1982.tb02763.x
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  • 4
    Electronic Resource
    Electronic Resource
    An immunohistological study of reactive lymphoid tissue (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 7 (1983), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to document the patterns of cytoplasmic Ig heavy and light chain expression in reactive lymphoid tissue, using single and double immunoenzymatic labelling techniques. This investigation was undertaken, firstly, to provide information on whether the normal counterparts of high grade lymphoma cells (e.g. centroblasts, immunoblasts) ever express more than one light or heavy chain (as has been noted in the past for lymphomas) and also, secondly, to seek evidence of intraclonal ‘switching’ from cytoplasmic IgM to cytoplasmic IgG expression. Paraffin embedded sections, all showing substantial reactive changes, were analysed by means of immunoperoxidase stains for the three major immunoglobulin classes (IgG, IgM and IgA), both light chain classes and J chain. In addition, double immunoenzymatic labelling techniques were used to search for cells showing simultaneous expression of kappa and lambda light chains and cells expressing mu and gamma heavy chain. Large transformed lymphocytes showing cytoplasmic Ig-staining in the pulp and interfollicular areas often have nuclear morphology indistinguishable from germinal centre centroblasts. There was no evidence of primitive appearing IgM-positive cells and IgG-positive cells of more mature morphology. In addition, immunoenzymatic staining showed that cells simultaneously expressing both IgG and IgM are only rarely encountered. When such cells were detected, the morphology was not that of a blast cell, but rather of a plasma cell containing Russell bodies. Hence it is suggested that cytoplasmic IgM switching to IgG is rarely detected by immunohistological methods in reactive tissue. Double staining for kappa and lambda revealed that cells simultaneously expressing both light chain types were not detected even among cells showing the most primitive morphology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1983.tb02298.x
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  • 5
    Electronic Resource
    Electronic Resource
    Eosinophilic granuloma of lymph nodes—a variant of histiocytosis X (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A clinicopathologic study of histiocytosis X in lymph nodes disclosed a special variant: primary eosinophilic granuloma of lymph nodes. This variant involves one or more lymph nodes, but does not infiltrate any other organs. Histologically, the infiltration of lymph nodes by histiocytosis X cells and eosinophils is similar to that seen in disseminated or metastatic histiocytosis X. Most cases of eosinophilic granuloma of lymph nodes are recognizable as primary, however, by the heavy infiltration of the surrounding tissue. The predominant proliferating cells are histiocytosis X cells (‘Langerhans cells’), which contain Birbeck granules on electron microscopy and are lysozyme-negative. The disease was found in 30 patients among a total of 64 cases of histiocytosis X collected at the Lymph Node Registry in Kiel. Primary eosinophilic granuloma of lymph nodes occurs predominantly in children and young adults and shows a slight preponderance of males. Clinically, the patients present with mostly afcbrile and sometimes painful lymphadenopathy, which is more often solitary (in the cervical or inguinal region) than widespread. The erythrocyte sedimentation rate and/or serum α2-globulin level are elevated in many patients. There may also be an increase in the number of leucocytes, especially eosinophils, in the blood. The prognosis is favourable: the lymphadenopathy disappeared spontaneously in most patients and only one patient developed two recurrences. Thus, primary eosophilic granuloma of lymph nodes is interpreted as a benign lesion. It might be a special reaction of the T cell system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02955.x
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  • 6
    Electronic Resource
    Electronic Resource
    Stoffwechseluntersuchungen an Lymphknoten und Tonsillen (1959)
    Springer
    Journal of molecular medicine 37 (1959), S. 1059-1064 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über Stoffwechseluntersuchungen an insgesamt 47 menschlichen Lymphknoten mit verschiedenen gutartigen und bösartigen Erkrankungen sowie an 10 menschlichen Gaumentonsillen mit chronischer hyperplastischer Entzündung berichtet. Wir bestimmten Sauerstoffverbrauch, Milchsäurebildung und Crabtree-Effekt an Gewebshomogenaten und kamen zu folgenden Ergebnissen: 1. Sauerstoffverbrauch und Milchsäurebildung zeigten bei den einzelnen Krankheitsgruppen erhebliche Schwankungen, offenbar als Ausdruck unterschiedlicher funktioneller Aktivität bzw. differenter funktioneller Aufgaben des lymphatischen Gewebes unter normalen und krankhaften Bedingungen. Charakteristische Gesetzmäßigkeiten konnten für keine Krankheitsgruppe ermittelt werden. Bemerkenswert scheinen die hohen aeroben Gärungswerte der fortgeschrittenen Lymphogranulomatose, wogegen die frische Lymphogranulomatose und das Paragranulom relativ niedrige Werte zeigten. 2. Der Crabtree-Effekt (verminderte Atmung in Anwesenheit von Glucose) war bei 12 von 27 Fällen gutartiger Lymphknotenerkrankungen und bei 3 von 10 Lymphknotentumoren sowie bei 5 von 10 Lymphogranulomatosen vorhanden; keine der 10 Gaumenmandeln zeigte einen sicheren Crabtree-Effekt. Demnach ist der Crabtree-Effekt kein konstantes, spezifisches Kennzeichen des Tumorstoffwechsels. Er kann somit nicht zur Abgrenzung gut- und bösartiger Gewebsveränderungen dienen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01482911
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  • 7
    Electronic Resource
    Electronic Resource
    Klinisches Bild und Prognose generalisierter Mastozytosen (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 785-793 
    Details
    ISSN: 1432-1440
    Keywords: Generalized mastocytosis ; Systemic mastocytosis ; Malignant mastocytosis ; Tissue mast cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proliferation of tissue mast cells in more than one organ is a rare disease, called generalized mastocytosis. Findings obtained in 35 cases were compared with 125 case reports in order to elucidate the course of the disease and its clinical picture. The results indicated that generalized mastocytosis has to be divided into two variants, designated systemic mastocytosis and malignant mastocytosis. Systemic mastocytosis is characterized by urticaria pigmentosa-like skin eruptions, with simultaneous infiltration of at least one visceral organ (usually bone marrow). Other frequently involved organs are spleen, liver, and lymph nodes. The age curve is biphasic, with one peak in early childhood and another in the 6th decade. The prognosis of systemic mastocytosis is generally favorable (actuarial survival 0.88 one year after diagnosis). In contrast to systemic mastocytosis, malignant mastocytosis does not show urticaria pigmentosa-like skin lesions. In this variant of generalized mastocytosis, frequently involved organs are bone marrow, spleen, liver, and lymph nodes. Common symptoms are anemia and eosinophilia. The age curve shows a peak in later life (6th and 7th decades). Malignant mastocytosis is never seen in children. The clinical course is usually rapid, and prognosis correspondingly poor (actuarial survival 0.23 one year after diagnosis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496722
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  • 8
    Electronic Resource
    Electronic Resource
    Lymph node enlargement due to amyloid (1983)
    Springer
    Virchows Archiv 399 (1983), S. 233-236 
    Details
    ISSN: 1432-2307
    Keywords: Amyloid ; Amyloidosis ; Lymph nodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a patient presenting with supraclavicular and cervical lymph node enlargement with demonstration of amyloid is presented. Histologic features are described. Amyloid deposition was not found in any other organ. Immunohistochemical typing with antisera raised against protein AA, Aλ, and Aκ showed a reaction only against Aλ. Thus, this case belongs to the immunoglobulin λ light chain-derived types that occur in many other parts of the body, particularly the respiratory tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619583
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  • 9
    Electronic Resource
    Electronic Resource
    Development of malignant lymphoma in myoepithelial sialadenitis (Sjögren's syndrome) (1982)
    Springer
    Virchows Archiv 395 (1982), S. 11-43 
    Details
    ISSN: 1432-2307
    Keywords: Myoepithelial sialadenitis ; Sjögren's syndrome ; Non-Hodgkin's lymphoma ; LP immunocytoma ; Immunoblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-five cases of myoepithelial sialadenitis (MESA) were investigated histologically, immunologically, and clinically. Two patients with clinical evidence of Sjögren's syndrome were also included in the study, though salivary gland biopsies showing MESA were not available. A total of 16 patients had Sjögren's syndrome or another type of autoimmune disease. In 42 cases of MESA, so-called proliferation areas composed of immunoblasts and lymphoplasmacytoid cells were found. The proliferation areas were small and circumscribed in 16 cases, and extensive and confluent in 26 cases. All the confluent proliferation areas analyzed with the immunoperoxidase (PAP) method showed a monotypic immunoglobulin pattern (predominantly IgM/κ). Extrasalivary malignant lymphoma with the same histologic and immunohistologic features as the confluent proliferation areas was found in 14 patients. Thus, this type of MESA is called “manifest malignant lymphoma”. The tumor was classified as LP immunocytoma in 23 patients, and as LP immunocytoma transforming into immunoblastic lymphoma in three patients. One patient developed nodal B-immunoblastic lymphoma. The term “early lymphoma” is suggested for MESA with circumscribed proliferation areas showing a monotypic immunoglobulin pattern (usually IgM/κ), because extrasalivary malignant lymphoma developed later in four of the patients with this type of MESA. The two patients with only clinical evidence of Sjögren's syndrome also showed extrasalivary malignant lymphoma (LP immunocytoma in one case and immunoblastic lymphoma in the other). There is a close histogenetic relation between MESA with or without autoimmune disease and certain malignant non-Hodgkin's lymphomas of B type, namely, LP immunocytoma and B-immunoblastic lymphoma. The interval between the appearance of salivary gland enlargement and the diagnosis of malignant lymphoma varied from 1.5 to 12 years. Generalization of malignant lymphoma led to death in 11 cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443482
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  • 10
    Electronic Resource
    Electronic Resource
    Histiocytic necrotizing lymphadenitis without granulocytic infiltration (1982)
    Springer
    Virchows Archiv 395 (1982), S. 257-271 
    Details
    ISSN: 1432-2307
    Keywords: Necrotizing lymphadenitis ; Histiocytic lymphadenitis ; Lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven cases of an unusual necrotizing lymphadenitis previously described only in Japan are reported as occurring in West Germany (23 cases), Iran (1 case), Italy (1 case), Korea (1 case) and Spain (1 case). The lesion frequently develops in the cervical lymph nodes of young women. It is characterized by infiltration of the cortex and/or paracortex by large collections of proliferating histiocytes and is devoid of granulocytes. Complete or, more often, incomplete necrosis of lymphoid tissue is seen in all cases. In cases with incomplete necrosis, the histiocytes are interspersed with pyknotic cells and nuclear debris. Based on the histological findings, the term “histiocytic necrotizing lymphadenitis without granulocytic infiltration” is proposed. Lesions to be considered in a differential diagnosis are malignant histiocytic neoplasms and necrotizing lymphadenitis with granulocytic infiltration, which is seen in lupus erythematosus and bacterial infections. The aetiology of histiocytic necrotizing lymphadenitis without granulocytic infiltration is still unclear. Some clinical and histological features indicate the possibility of an underlying viral infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429352
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