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  • Electronic Resource  (5)
  • 1980-1984  (5)
  • genetics  (3)
  • Hallucinogens  (2)
  • 1
    ISSN: 1432-2072
    Keywords: Hallucinogens ; Discriminative stimulus ; Serotonin receptor affinities ; 5-OMe DMT ; Tryptamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r=-0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: 5-OMeDMT ; Discriminative stimulus ; LSD ; Hallucinogens ; BC-105 ; Operant responding ; Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5 mg/kg or 3.0 mg/kg 5-OMeDMT from saline. A series of antagonist and generalization tests revealed that (1) antagonism of the 5-OMeDMT stimulus response by the presumed serotonin antagonist BC-105 depended on the dose of 5-OMeDMT, (2) the 5-OMe DMT stimulus generalized to LSD, and (3) like 5-OMeDMT, antagonism of the LSD generalization response by BC-105 depended on the dose of LSD. In a second study, with rats responding under a variable-interval (VI) 15-s schedule of reinforcement, doses of 1.0–3.0 mg/kg 5-OMeDMT significantly decreased response rate. Furthermore, the decrease in responding produced by the administration of 1.5 mg/kg (but not by 3.0 mg/kg) 5-OMeDMT was blocked by BC-105. This dosedependent antagonism was of particular interest since the 1.5 mg/kg and 3.0 mg/kg dose of 5-O-MeDMT had essentially the same effect on responding when given alone. The results of both studies emphasize the importance of 5-OMeDMT dose in antagonism experiments.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 12 (1982), S. 111-121 
    ISSN: 1573-3297
    Keywords: neurotransmitters ; genetics ; quantitative genetics ; pharmacology ; environment ; genetic correlations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Genetic studies of neurotransmitter processes to date differ from most behavioral genetic studies in that the former have rarely considered individual variability, have tended to look only for single-gene effects, and generally have overlooked or ignored environmental influences. After examining these differences, we suggest that a rapprochement between the two fields will yield synergistic benefits in studies of the genetics of neuropharmacological processes as they affect behavior.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-5060
    Keywords: Pelargonium × hortorum ; Pelargonium ; fertilization ; embryo survival ; plastid crosses ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The 6×6×4 analysis of variance of the mean percentage embryo survival for six variegated cultivars of Pelargonium × hortorum Bailey, with mutant plastids in their germ layers, and for their isogenic green (G) clones, shows highly significant differences between females (81 to 91 per cent) and between plastid crosses (83 to 91 per cent). Between cultivar differences are attributed largely to additive effects corresponding to additive gene action, and between plastid differences to a lower survival after crosses with white (W) males than with green males. The relationship between overall fertility (% fertilization × survival) and plastid crosses is a stepwise decline in the order G×G〉G×W〉W×G〉W×W (28 to 19 per cent) in which the white embryos growing in a white mother are approximately 30 per cent less fertile than the green embryos in a green mother. The non-surviving embryos are classified into empty, undeveloped and dwarf embryos and submitted to a 6×4 analysis of variance after summing through males. The significant heterogeneity between females is attributed largely to a difference between one cultivar-with a high frequency of dwarf and a low frequency of undeveloped embryos-and the other five cultivars. The absence of a significant plastid effect upon any stage of embryo breakdown indicates that the depressive effect of white plastids is spread evenly throughout development.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 33 (1984), S. 169-176 
    ISSN: 1573-5060
    Keywords: Mirabilis jalapa ; marvel of Peru ; four o'clock ; leaf variegation ; mutable genes ; controlling elements ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The recurrent back-mutation from homozygous recessive chlorina to heterozygous dominant green in leaves of variegated Mirabilis jalapa is explicable on the hypothesis of a controlling element system. The analysis of variance of mutation frequency suggests that there is polygenic control modifying the major regulatory gene, an idea which is supported by a significant parent offspring regression. There is also evidence for a change of state in the regulatory element giving rise to a new mutability pattern.
    Type of Medium: Electronic Resource
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