ISSN:
1573-8744
Keywords:
bioavailability
;
bioequivalence
;
hypothesis tests
;
sample size determination
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The clinical problem of testing for equivalence in comparative bioavailability trials is restated in terms of the proper statistical hypotheses. A simple t-test procedure for these hypotheses has been devloped that is more powerful than the methods based on usual (shortest) and symmetric confidence intervals. In this note, this new procedure is explained and an example is given, including the method for sample size determination.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01063612
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