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  • Electronic Resource  (2)
  • 1980-1984  (2)
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  • Electronic Resource  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Exacerbation of experimental poly-d-lysine arthritis by C-reactive protein (1982)
    Springer
    Inflammation research 12 (1982), S. 344-347 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rabbit C-reactive protein (Cx-rp) was able to induce a prolonged exacerbation of inflammation when injected locally into arthritic rabbit knee joints. The increase in the level of inflammation, measured as the change in joint temperature, was accompanied by an increase in serum Cx-rp levels. Locally administered Cx-rp had no effect on joint swelling. Cx-rp, when injected locally into normal knee joints, had no effect on temperature or swelling. Cx-rp was unable to induce its own synthesis when injected intravenously into normal rabbits. The findings support a role for Cx-rp as a positive modulator of acute inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965401
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of experimental poly-d-lysine arthritis in rabbits by non-steroidal anti-inflammatory compounds (1981)
    Springer
    Inflammation research 11 (1981), S. 260-264 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of five non-steroidal anti-inflammatory compounds on experimental poly-d-lysine arthritis in the rabbit knee joint have been determined. Two non-invasive methods of assessing the inflammation, measurement of swelling and temperature have been used to follow the effect of treatment. The rank order of potency for the reduction of temperature was indomethacin 〉 flurbiprofen 〉 diclofenac sodium 〉 sulindac 〉 fenclofenac. Reduction in joint temperature was shown not to be due to a vasoconstrictor effect. Reduction of swelling was variable and not doserelated. The method described allows the activity of such compounds on experimental articular arthritis to be determined rapidly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967624
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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