ISSN:
1432-1335
Keywords:
Yoshida ascites tumor
;
Cyclophosphamide
;
Alkylating agents
;
Resistance and cross resistance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A cyclophosphamide-resistant subline of a Yoshida ascites tumor was developed by giving increasing doses of the drug after transplantation. The effect of several alkylating agents on the cell proliferation of both the sensitive and resistant cell line was compared establishing dose response curves and D50 values. The developed subline revealed a 260 fold resistance to cyclophosphamide. It was completely cross-resistant to hydroperoxycyclophosphamide, whereas for triaziquone, N-oxide-mustard, and N-methyl-mustard only a partial cross resistance existed. These results give further evidence that cyclophosphamide and hydroperoxycyclophosphamide have the same mechanism of action. Regarding the other alkylating agents the results demonstrate differences concerning either the molecular mode of action or protecting effects. A decreased activation or uptake of substance is probably not the base for resistance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00419285
Permalink
