ISSN:
1432-2072
Keywords:
Uptake
;
Platelets
;
5-Hydroxytryptamine
;
Dopamine
;
Inhibition
;
Protriptyline
;
Clomipramine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of protriptyline and clomipramine, at concentrations of 10−7 M to 10−4 M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5×10−8 M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00437621
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