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  • Digitale Medien  (3)
  • 1975-1979  (3)
Materialart
  • Digitale Medien  (3)
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  • 1
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A comparative study of tissue gold levels produced in guinea-pigs after the oral administration of either triethyl-phosphine gold chloride or Myocrisin (sodium aurothiomalate) or after the injection of Myocrisin intramuscularly is reported. Gold concentrations were determined 5, 24 and 168 hours after administration in stomach, small intestine, large intestine, kidney, liver and spleen and 5 and 24 hours after administration in skin, adrenals, heart, lung and brain. In gastrointestinal tissues, tissue gold concentrations were highest with triethylphosphine gold chloride. The stomach gold level 5 hours after oral administration of triethyl-phosphine gold chloride is particularly high and, taken in conjunction with the other gastrointestinal gold levels measured, suggests that a stomach rather than an intestinal absorption mechanism may predominate. A more extensive time-course study on kidney and liver is reported and the possible relationship between tissue concentration and toxicity is discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Total serum copper levels produced by the administration of a single dose of cuprous oxide (500 mg/kg) both s.c. and orally to rats and guinea pigs are reported 1, 5, 7 and 24 h after administration, together with caeruloplasmin oxidase activities and changes in the sulphydryl group concentrations. The highest serum copper levels were obtained one hour after oral administration to the guinea pig. Both animal species exhibited increased serum copper levels after s.c. administration and this increase persisted for a longer time than after oral administration. Caeruloplasmin oxidase activity varied in a complex manner and sulphydryl group activity was significantly depressed in all cases except after s.c. administration to the guinea pig. The latter results must be treated cautiously since they may indicate interactions between copper and the test procedures. Analysis of serum fractions separated by electrophoresis indicated that the absorbed copper is mainly transported on albumin. The dissolution of cuprous oxide by amino acids and hydrochloric acid and the absorption of cuprous oxide and some related copper complexes by albumin were investigated in vitro. The implications of the results are discussed in terms of their relevance to pharmacological and clinical studies.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Numerische Mathematik 30 (1978), S. 415-428 
    ISSN: 0945-3245
    Schlagwort(e): AMS(MOS). 65D30 ; CR: 5.16
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Summary This paper is concerned with the theoretical properties of a productintegration method for the integral $$\int\limits_{ - 1}^1 {k(x)f(x)dx}$$ , wherek is absolutely integrable andf is continuous. The integral is approximated by $$\sum\limits_{i = 0}^n {w_{ni} f(x_{ni} )}$$ , where the points are given byx ni =cos(iπ/n, 0≦i≦n, and where the weightsw ni are chosen to make the rule exact iff is any polynomial of degree ≦n. The principal result is that ifk∈L p [−1, 1] for somep〉1, then the rule converges to the exact result asn→∞ for all continuous (or indeed R-integrable) functionsf, and moreover that the sum of the absolute values of the weights converges to the least possible value, namely $$\int\limits_{ - 1}^1 {|k(x)|dx}$$ . A limiting expression for the individual weights is also obtained, under certain assumptions. The results are exteded to other point sets of a similar kind, including the classical Chebyshev points.
    Materialart: Digitale Medien
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