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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 1-9 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— We describe a method for the fluorometric determination of 5-hydroxyindoles in the physiological range of 0.010–1.30 μg/ml of whole blood by means of an autoanalytical procedure. Serotonin is dialysed free from haemolysed blood constituents and a complex between 5-HT and o-phthaldialdehyde is formed in the dialysand to provide a considerable increase over the native fluorescence of 5-HT in strong acid. The method has been evaluated and considered to be accurate for the continuous monitoring of levels of 5-HT in whole blood and for the determination of cerebral arteriovenous differences. The range of values for human patients with cerebrovascular disease was 0.09–0.34 μg/ml of whole blood. In experimental studies on the baboon the range was 0.538–1.28 μg/ml. A mean positive cerebral arteriovenous difference for 5-HT (and possibly other 5-hydroxyindoles) of 0.037 μg/ml was measured in 10 baboons. This finding suggests the possibility of physiological movement of 5-HT and 5-hydroxyindoles into brain across the blood-brain barrier.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 5 (1972), S. 130-132 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 5 (1972), S. 464-470 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 6 (1973), S. 176-180 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 2 (1973), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Male weanling rats were fed a diet containing 1.3 mg zinc/kg diet and controls the same diet supplemented by 40 mg /zinc/kg diet. The rates of cell division and upward migration in the cheek epithelium were obtained from counts of labelled cells in animals sacrificed one hour and three days following intraperitoneal injection of 1 μCi tritiated thymidine/g body weight. A 3.4-fold increase over the number of labelled cells in controls was observed one hour after thymidine administration and a 2.7-fold increase three days later. Ratios of labelled cells at three days and one hour were 4.96 in controls and 3.99 in experimental animals. The percentage distribution of labelled cells in successive subdivisions of epithelium was identical in both groups. The number of labelled cells near the junction of granular and keratin layers was 2.9-fold greater in the experimental animals.It is suggested that the zinc-deficient cheek epithelium of the rat might be a useful model for the study of pathological conditions associated with increased rates of cell proliferation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 242 (1971), S. 332-341 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Large quadrupole moments of 1-phonon states of sperical nuclei are shown to follow in a simple and direct way from time-dependent HF equations using the self-consistent perturbation expansion. Whereas the first order describes harmonic quadrupole oscillations, anharmonic terms arise in second order. The scattering of quasiparticles by quasi-particle pairs, which is neglected in RPA calculations, but included in this paper, leads to a second order response of the system and is shown to produce a strong enhancement of the quadrupole moments. Explicit results are obtained with a pairing-plus-quadrupole interaction and discussed within a schematic two level model.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 387-400 
    ISSN: 1432-1912
    Keywords: Myocardial Infarction ; Coronary Blood Flow ; Epicardial Mapping ; Nitroglycerin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of nitroglycerin (N.G.) on the size of myocardial infarction was studied in 12 open-chest dogs with chloralose-urethane anesthesia by means of epicardial ECG-mapping and compared with the influence of simple ligature of the same coronary artery branch. In order to identify the specific effect of N.G. on the heart and the coronary circulation without contribution of the peripheral circulation in 6 dogs aortic pressure was stabilized by a clamp placed around the descending aorta and heart rate was kept constant by atrial pacing. Nitroglycerin (0.5 mg/kg i.v.) infused during the occlusion period of 20 min resulted in a decrease of mean arterial pressure for 27 mm Hg (p〈0.005) and left ventricular enddiastolic pressure for 2 mm Hg (p〈0.05) indicating a diminishment in oxygen demand. Mean coronary blood flow was reduced to a similar extent (18%) as in the control infarction (22%). Compared to simple occlusion no significant alteration in the extent of ST-elevation in the epicardial electrogram was observed during N.G.-infusion even in the presence of hypotension. In the stabilized group with constant afterload (mean arterial pressure) and heart rate nitroglycerin induced a slight, but not significant decrease of the enddiastolic left ventricular pressure compared to the control group. However, coronary blood flow and ST-elevation were unaffected. Thus, neither in the unstabilized nor in the stabilized group the extent of myocardial injury after ligature of a coronary artery branch were influenced by nitroglycerin. Obviously the improvement in the oxygen demand during nitroglycerin is out balanced by the reduction in oxygen supply so that in effect myocardial infarction size is not altered by N.G. as estimated from epicardial ECG.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 10 (1972), S. 91-102 
    ISSN: 1432-0827
    Keywords: Hydroxyapatite ; Calcification ; Phases ; Growth ; Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé La croissance cristalline de l'hydroxyleapatite à 25° et à pH constant de 7.4 a été étudiée à l'aide du microscope électronique à balayage. La technique reproductible de croissance par ensemencement à partir de solutions stables sursaturées est utilisée efficacement pour produire des échantillons de minéral à divers stades distincts de croissance. Des changements de phase sont observés avec le progrès de la croissance; ils correspondent dans le temps avec les résultats cinétiques obtenus antérieurement. Un essai de rationalisation est tenté à la lumière des mécanismes proposés pour la formation d'hydroxyleapatite dans des conditionsin vivo.
    Abstract: Zusammenfassung Das Kristallwachstum von Hydroxyapatit bei 25° und einem konstanten pH von 7,4 wurde mit Hilfe eines Raster-Elektronenmikroskopes studiert. Die reproduzierbare Technik des Keimwachstums aus stabilen übersättigten Lösungen wurde mit Erfolg verwendet, um Mineralproben in verschiedenen bestimmten Stadien des Wachstums zu erhalten. Phasenveränderungen wurden beim fortschreitenden Wachstum beobachtet, und diese stimmten zeitlich gut überein mit kinetischen Resultaten, über welche früher berichtet wurde. Es wurde versucht, diese Beobachtungen zu erklären in Anbetracht von Mechanismen, welche für die Bildung von Hydroxyapatit unterin vivo-Bedingungen vorgeschlagen wurden.
    Notes: Abstract The crystal growth of hydroxyapatite at 25° and at a constant pH of 7.4 has been studied with the aid of a scanning electron microscope. The reproducible technique of seeded growth from stable supersaturated solutions was used effectively to produce samples of the mineral at various distinct stages of growth. Phase changes were observed as the growth proceeded and these corresponded favorably in time with kinetic results reported earlier. An attempt was made to rationalize the observations in light of mechanisms proposed for the formation of hydroxyapatite under conditions foundin vivo.
    Type of Medium: Electronic Resource
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