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Digitale Medien

LEVELS OF METABOLITES AND PRODUCTION OF GLUCOSE IN THE LAMPREY BRAIN (1969)

Rovainen, C. M. ; Lowry, O. H. ; Passonneau, J. V.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 16 (1969), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: —The levels of ATP, phosphocreatine, glucose, glucose-6-P., lactate, and glycogen have been measured in brains and spinal cords of lamprey larvae. Levels of glycogen in the brains were high, sometimes exceeding 100 m-moles of glycosyl units/kg wet weight. Isolated brains incubated in oxygenated saline exhibited the same levels of ATP and phosphocreatine as brains of intact animals. The level of glucose in tissue water of isolated brains approximated that found in the medium, except at low concentrations where the brains maintained levels of glucose many times that of the medium. It is demonstrated that under metabolic stress lamprey brains produce glucose by the breakdown of glycogen and the probable action of a glucose-6-phosphatase. The hypothesis is proposed that cells of the brain exchange glucose by this mechanism.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb09897.x

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