ISSN:
1432-072X
Keywords:
Key words Motility
;
Chemotaxis
;
Gene regulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract BvgAS is a two-component system of Bordetella pertussis involved in the reciprocal regulation of the virulence genes and the flagellar biosynthesis. In this study, we found that expression of bvgAS in Escherichia coli also results in reduced motility. The repression was relieved by the addition of known chemical modulators of BvgAS such as MgSO4 and nicotinic acid, indicating that functional BvgAS proteins are required for the negative control of E. coli motility. In addition, BvgAS repressed the transcription of the flhDC master operon of E. coli, which consequently caused non-flagellation on the cell surface. However, expression of BvgAS had no effect on stress-resistant motile mutants of E. coli. These data suggest that E. coli may have BvgA-like protein(s) involved in the regulatory interactions between the stress response and the flagellar biosynthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002030050688
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