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  • 1
    ISSN: 1432-0428
    Keywords: Key words Glucagon ; insulin secretion ; exendin (9 ; 39) ; GLP-1 ; pancreas perfusion.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since glucagon-like peptide-1 (7–36) amide (7–37) (GLP-1) has been found to be a potent insulinotropic hormone, it has been postulated that glucagon stimulates insulin secretion from islet beta cells through the GLP-1 receptor. We therefore examined the effects of a GLP-1 receptor antagonist, exendin (9–39) amide, on glucagon- or GLP-1-stimulated insulin release from isolated perfused rat pancreas. When infusion of 100 nmol/l exendin (9–39) amide was started 5 min before that of 1 nmol/l glucagon, the stimulation of insulin release by glucagon was similar to that found in the control situation (preinfusion with vehicle alone). By contrast, when 0.3 nmol/l GLP-1 was used in the same experimental setting, exendin (9–39) amide clearly inhibited insulin release. These results indicate that glucagon stimulates insulin release mainly through glucagon receptors but not GLP-1 receptors on islet beta cells. [Diabetologia (1995) 38: 274–276]
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1536
    Keywords: Key words Hybrid titania ; Photocatalysis ; Visible light ; Ru(2 ; 2′-bipyridyl)3Cl2 ; Polymer modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The preparation and photocatalysis of colloidal titania modified with Ru(2,2′-bipyridyl)3 2+-grafted polyacrylate were investigated. Visible light irradiation of the Ru(2,2′-bipyridyl)3 2+-tethered titania in pH 7.0 buffer solution gave electron transfer to methyl viologen to form the cation radical via electron migration from the Ru(II) complex to the titania surface.
    Type of Medium: Electronic Resource
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