ISSN:
1432-2072
Keywords:
Tremorine
;
Tolerance
;
Analgesia
;
Parachlorophenylalanine
;
5-hydroxytryptophan, l-Dopa, α-methyl-para-tyrosine
;
Theophylline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalanine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxytryptophan, l-Dopa or α-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00439113
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