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  • Electronic Resource  (5)
  • 82.65  (3)
  • Key words Non-small-cell lung cancer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 238-245 
    Details
    ISSN: 1432-1335
    Keywords: Key words Non-small-cell lung cancer ; Neoadjuvant therapy ; p53 ; Single-strand conformation polymorphism (SSCP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a phase II study for optimizing therapeutic management of locally advanced non-small-cell lung cancer the prognostic and therapeutic relevance of the p53 status was investigated. Biopsy or mediastinoscopy samples, collected prior to neoadjuvant chemoradiotherapy and corresponding resection specimens, were analysed immunohistochemically (CM1 antiserum) for p53 accumulation and molecular biologically (polymerase chain reaction/single-strand conformation polymorphism) for p53 mutations. The results were correlated to the response to therapy (regression grade) and to the survival times. p53 accumulation was found in 41.7% (prior to neoadjuvant therapy) and in 40.0% (after surgery) of the tumours. p53 mutation was demonstrated in 45.4% (prior to neoadjuvant therapy) and in 46.4% (after surgery) of the investigated tumours. Neither before nor after therapy was any correlation to the survival times or to the response to therapy seen in the collective analysed. Thus, such investigations are not suitable for identifying patients with locally advanced non-small-cell lung cancer who might benefit, to different extents, from neoadjuvant therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050039
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  • 2
    Electronic Resource
    Electronic Resource
    SIMS and flash desorption studies of nickel oxygen interaction (1978)
    Springer
    Applied physics 16 (1978), S. 367-373 
    Details
    ISSN: 1432-0630
    Keywords: 79.20 ; 82.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract O2 exposure of polycrystalline nickel at 300 K results in characteristics changes of secondary ion emission. These can be described by a model which is in good agreement with corresponding LEED, AES, XPS, and ΔΦ results of other authors. According to this model, oxygen can be bonded on Ni in at least five different phases: 1) chemisorption, indicated by a rapid increase of Ni+, Ni 2 + , and Ni2O+ (≦5 L); 2) a rearranged chemisorption layer, characterized by a drastic decrease of Ni+, Ni 2 + , and Ni2O+ (5–15 L); 3) nickel oxide (NiO) responsible for a strong NiO−- and NiO 2 − -emission (≦40 L); 4) oxygen on top of this NiO layer, producing a final increase of Ni+ and NiO+ and a O2-flash signal at 400 K (〉40 L); 5) bulk dissolved oxygen in thermal equilibrium with a chemisorption layer (after several exposure/heating cycles). During ion bombardment of a 100 L O2 exposed Ni surface these different binding states occur in a reversed order of succession. O2-flash signals at 400 and 1100 K, related to drastic changes in secondary ion emission at 400, 700, and 1100 K, reflect the disappearance of various oxygen binding states. The exchange between different oxygen phases was studied by16O2/18O2 isotope experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00885861
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  • 3
    Electronic Resource
    Electronic Resource
    Fast LEED intensity measurements with a video camera and a video tape recorder (1979)
    Springer
    Applied physics 19 (1979), S. 287-293 
    Details
    ISSN: 1432-0630
    Keywords: 06.90+v ; 61.14-x ; 82.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The measurement of LEED intensities with a TV camera-computer system, which has been published in an earlier paper, is reported to be improved with respect to the speed of data collection by a factor of about 102. Other properties such as sensitivity, reliability and handling facility have also been improved. The new measuring mode, which applies a video tape recorder, allows the simultaneous measurement of all appearing diffraction spots down to a beam current of 10−11 A with a rate of 50 energy points/s. This pushes the total measuring time for LEED spectra to the order of seconds and makes possible to monitor non-stable surfaces. As an example intensity measurements for different adsorption stages of hydrogen on W(100) are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00900472
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  • 4
    Electronic Resource
    Electronic Resource
    Some aspects of auger electron spectra of 3d transition metal oxides (1977)
    Springer
    Applied physics 13 (1977), S. 43-46 
    Details
    ISSN: 1432-0630
    Keywords: 79.20 ; 82.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Auger electron spectra of the transition metals Cr, Mn, Fe, Co and Ni as well as their oxides have been investigated in the energy range between 0–100 eV. In each case of the clean metal surface the observed spectrum consists essentially of one Auger line identified asM 2,3 VV transition. After oxidation a line doublet is observed revealing two transitions instead of one. Additional new Auger peaks appear in the low energy range between 0–30 eV. The “splitting” of the Auger line can be explained as resulting from aM 2,3 V dVd and aM 2,3 V pVp transition. The latter is characteristic for the compound and can in a simple way be interpreted as a cross transition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00890718
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  • 5
    Electronic Resource
    Electronic Resource
    Tumour regression in non-small-cell lung cancer following neoadjuvant therapy. Histological assessment (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 469-477 
    Details
    ISSN: 1432-1335
    Keywords: Key words Non-small-cell lung cancer ; Neoadjuvant therapy ; Regression grading ; Therapy-induced tumour regression ; Spontaneous tumour regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the scope of a prospective multi-centre study after neoadjuvant combined chemotherapy (carboplatin, ifosfamide, etoposide, vindesine) and radiotherapy (45 Gy) 40 resection specimens of locally advanced non-small-cell lung cancer were analysed in order to establish reproducible pathological/anatomical results of tumour regression. Resection specimens of 28 squamous cell carcinomas and 12 adenocarcinomas were investigated using serial sections of the primary lesion. The mean age of the patients was 57 years. The results were compared to spontaneous regressive changes in a control group of 50 untreated non-small-cell lung cancers. Marked scarry fibrosis in the region of the former primary tumour, concentric foci of fresh tumour necroses and surrounding foam cell clusters with transition into vascular granulation tissue could be established as characteristic features of therapy-induced tumour regression, whereas untreated carcinomas revealed necroses with adjoining vital tumour tissue. Using a three-step regression system, 3 tumours could be classified as grade I (no or only slight tumour regression), 10 tumours as grade IIA (marked but incomplete tumour regression, more than 10% vital tumour tissue), 20 tumours as grade IIB (less than 10% vital tumour tissue) and 7 tumours as grade III (complete tumour regression without vital tumour tissue). After a median follow-up period of 32.3 months in patients with grade IIB or III tumour regression (“responders”) the median survival time of 27.9 months was found to be significantly longer than in patients with grade I or IIA tumour regression (“non-responders”) with a median survival period of 13.7 months (log-rank test, P=0.020). The resection specimens analysed, which were obtained 7 weeks (on average) after the end of radiochemotherapy, did not show specific changes due to preoperative therapy, but quite characteristic histological alterations in the former tumour area were registered, which had been induced by combined neoadjuvant radiation and chemotherapy. The grade of therapy-induced tumour regression could be shown to be a significant prognostic factor in non-small-cell lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050090
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    Paper (German National Licenses)
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