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  • Electronic Resource  (2)
  • Acetylcyanamide  (1)
  • Autopsiebefunde, Dokumentation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 82 (1978), S. 157-164 
    ISSN: 1437-1596
    Keywords: Documentation of Autopsies ; Violent Death Documentation ; Autopsiebefunde, Dokumentation ; Dokumentation, Autopsiebefunde ; Gewaltsamer Tod, Dokumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es wird über die Erstellung einer Dokumentation des gesamten Obduktionsgutes des Institutes für Rechtsmedizin der Universität München (über 30.000 Fälle) aus den Jahren 1911-1974 berichtet. Die Auswertung der hierin enthaltenen „Gewaltsamen Todesursachen” ergab u.a. folgende Resultate: An den Verkehrsunfällen ist der historische Trend der Motorisierung abzulesen. Bei Tötungen mit Waffen zeigt sich seit 1965 eine deutliche Zunahme. Vergiftungen, nach dem 2. Weltkrieg stark angestiegen, werden heute mit anderen Mitteln durch geführt als vor 1955. Der prozentuale Anteil der Todesursachen bei äußerer Er stickung ist über die Zeit etwa gleich geblieben. Tödliche Abtreibungen sind nach 1946 deutlich zurückgegangen. Obduktionen wegen tödlicher Geburtsverletzun gen, vor und im 2. Weltkrieg an Häufigkeit z. B. mit tödlichen Intoxikationen zu vergleichen, stellen heute eine Seltenheit dar. Der Vorteil der raschen Zugriffs möglichkeit zu Fällen mit seltenen Todesursachen wird diskutiert.
    Notes: Summary We receiwed cases of violent death from more than 30,000 autopsies made at the Institute of Legal Medicine of the Munich University in the years 1911–1974 with the following results: The historical trend in motorisation is among others the following results: The historical trend in motorisation can be reflected by the number of traffic accidents. Killing by use of arms have increased significantly since 1965. Since the end of World War 11 there have been many more cases of poisoning, which today occur with different substances as compared with those used up to 1955. The percentage of death caused by suffocation due to external causes remained almost the same during the analysed period. Fatal abortions have declined distinctly since 1946. Up to the end of World War II autopsies resulting from birth injuries are comparable in frequency to, e.g., fatal intoxications; nowadays the are a rarity. The advantage of ready access to cases of rare death causes is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0738
    Keywords: Hydrogen cyanamide ; Rat ; Human ; Metabolism ; Urinary excretion ; Acetylcyanamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The main urinary metabolite of hydrogen cyanamide (syn.: cyanamide) in rat and man is acetylcyanamide (syn.: N-acetylcyanamide). An analytical method was developed to determine acetylcyanamide in the urine with a limit of quantification of 〈10 μg/l (mean recovery 96.1 % using spikes of 20 μg/l; relative standard deviation 〈4%). This methodology is based upon ion chromatography using column-switch techniques and UV detection. It could be demonstrated that in rats an average of 45.6% of oral applied cyanamide (10 mg/kg) was excreted in the urine as acetylcyanamide. In male human volunteers a mean of 40% of oral administered cyanamide (mean dose 0.25 mg/kg body weight) was excreted via the urine as acetylcyanamide. The same group of volunteers participated in a skin absorption study with dermal application of the above cyanamide dose onto a skin surface area of 32 cm2. Within an application period of 6 h an average cyanamide quantity of 2.3 mg was available for skin absorption. A mean portion of 7.7% of this quantity was found as acetylcyanamide in the urine of the participants. Findings from literature state that cyanamide is metabolized in vitro to cyanide. According to examinations performed in vivo, however, such a metabolic pathway seems to be irrelevant for man. In comparison with the control values there was no significant increase of both the cyanide concentrations in the blood and the thiocyanate concentrations in the urine of the above volunteers after the described oral cyanamide administration.
    Type of Medium: Electronic Resource
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