ISSN:
1433-8491
Keywords:
Amitriptyline
;
Nortriptyline
;
Hydroxylated metabolites
;
Oxidation polymorphism
;
Hydroxylation polymorphism
;
Pharmacogenetics
;
Interindividual differences
;
Pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have measured the metabolites (demethylated and hydroxylated) of amitriptyline in a group of seven normal volunteers. They were phenotyped as extensive or poor metabolizers using debrisoquine and bufuralol. The results demonstrate that the oxidative metabolism (aliphatic hydroxylation) of amitriptyline is under the same genetic control as that of debrisoquine and bufuralol. However, phenotypic polymorphism cannot be used to predict amitriptyline blood concentration after a single oral dose, since the principal metabolic pathway of amitriptyline is demethylation and not aliphatic hydroxylation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02141782
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