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  • Electronic Resource  (2)
  • Amphetamine  (1)
  • Apomorphine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Unilateral neonatal intracerebroventricular 6-hydroxydopamine administration in rats: II. Effects on extracellular monoamine, acetylcholine and adenosine levels monitored with in vivo microdialysis (1994)
    Springer
    Psychopharmacology 116 (1994), S. 451-456 
    Details
    ISSN: 1432-2072
    Keywords: 6-Hydroxydopamine ; Neonatal ; Unilateral ; Microdialysis ; Amphetamine ; Dopamine ; Serotonin ; Acetylcholine ; Adenosine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 6-hydroxydopamine (6-OHDA, 100 µg in 5 µl) was injected into the right ventricle of 3-day-old Sprague-Dawley rats in order to produce a unilateral dopamine (DA) lesion. At adult stage, the rats were implanted with microdialysis probes into the left and right striata. On the injected side, basal extracellular levels of DA were reduced by 〉65%, as compared to the contralateral side or to the levels found in vehicle-injected rats. Extracellular 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were reduced by 〉95%, while acetylcholine (ACh) was decreased by 〉50%.d-Amphetamine (2 mg/kg SC) produced a 10-fold increase in extracellular DA levels in the striatum contralateral to the 6-OHDA-injected side, while on the ipsilateral side, DA levels were not affected byd-amphetamine.d-Amphetamine produced an increase (〉2 fold) in extracellular ACh levels, on both ipsilateral and contralateral sides. Choline and adenosine levels were unaffected by any of the experimental conditions. Thus, neonatal unilateral ICV administration of 6-OHDA produced an ipsilateral decrease in striatal extracellular DA, DOPAC and HVA levels, compared to the contralateral side. A reduction of extracellular ACh levels was also observed on the 6-OHDA-injected side. The DA releasing effect ofd-amphetamine was abolished on the 6-OHDA-injected side, but not that on ACh levels, indicating that striatal DA and AChd-amphetamine-induced release are produced by independent mechanisms in the meonatally unilateral 6-OHDA-treated animals. As a whole the present study gives evidence showing that neonatal unilateral ICV treatment with 6-OHDA produces a predominantly unilateral lesion of the mesencephalic DA systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247477
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Unilateral neonatal intracerebroventricular 6-hydroxydopamine administration in rats: I. Effects on spontaneous and drug-induced rotational behaviour and on postmortem monoamine levels (1994)
    Springer
    Psychopharmacology 116 (1994), S. 443-450 
    Details
    ISSN: 1432-2072
    Keywords: 6-Hydroxydopamine ; Neonatal lesion ; Rotational behavior ; d-Amphetamine ; Apomorphine ; p-Chloroamphetamine ; Caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 6-Hydroxydopamine (6-OHDA; 100 µg in 5 µl) was injected into the right ventricle (intracerebroventricular, ICV) of 3-day old Sprague-Dawley rats in an attempt to produce a unilateral neonatal dopamine (DA) lesion. At adult stage, the rats were studied for spontaneous, handling- and drug-induced rotational behaviour. The 6-OHDA-treated rats showed hyperreactivity at handling, in the animal facility and in the experimental sets. This behaviour was not observed in vehicle-treated rats, and it did not decrease through the successive experiments. Apomorphine (0.05–1 mg/kg, SC) and caffeine (20 mg/kg SC) produced contralateral rotation in neonatal 6-OHDA, but not in vehicle-injected rats.d-Amphetamine (0.2–2 mg/kg, SC) produced strong, dose-dependent, ipsilateral rotation, while the serotonin (5-HT) releasing agent,p-chloroamphetamine (2 mg/kg, SC) produced a short-lasting and weak ipsilateral rotation in the 6-OHDA-treated rats. On the 6-OHDA-injected side, DA and metabolites levels were reduced by 〉70–90% in the striatum, the nucleus accumbens and the tuberculum olfactorium, while in the mesencephalon a 50% decrease was found. On the contralateral side, restricted decreases in DA and metabolites were observed. Noradrenaline (NA) levels were decreased bilaterally in the forebrain. In contrast, 5-HT and 5-hydroxyin-doleacetic acid (5-HIAA) levels were increased in the ipsilateral striatum (〉180%), and tuberculum olfactorium (〉120%). Thus, neonatal unilateral ICV 6-OHDA administration produced a significant unilateral decrease in tissue levels of DA and metabolites, which was most marked in the striatum. Changes in NA and 5-HT levels were also found in telencephalic and mesencephalic regions. The 6-OHDA lesion led to a lasting handling-related hyper-reactivity and, following stimulation with direct or indirect DA agonists, to rotational behaviour with a pattern similar to that observed in rats unilaterally lesioned at adult stage with 6-OHDA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247476
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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