ISSN:
0749-1581
Keywords:
2H NMR
;
Reversed micelle
;
Heavy water
;
Anaesthetic
;
Enflurane
;
Clathrate formation
;
Hydrogen bond breaking
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The behaviour of water in the reversed micelles of the glycerol α-monooleate (GMO)-decane-2H2O system was investigated by deuteron nuclear magnetic resonance. The chemical shifts (δ) and the spin-lattice relaxation times (T1) of heavy water were found to be dependent on temperature. The temperature dependence of the T1 and δ values reveals that the structural change in heavy water induced by the inhalation anaesthetic enflurane is very different below and above ca. 300 K. Below ca. 300 K a cage of a water polyhedron builds up around an enflurane molecule. Above ca. 300 K there is no water polyhedron cage because of the cleavage of the hydrogen bonds in the polyhedron water, and some of the water molecules are tightly adsorbed on the enflurane molecules.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260270409
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