ISSN:
0935-6304
Keywords:
Gas chromatography/ECD
;
Capillary, fused silica
;
Isosorbide dinitrate
;
Isosorbide-/isomannide-/isoidide-mononitrates
;
Human plasma
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide-2-mononitrate, isosorbide-5-mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate and o-nitrobenzyl alcohol from plasma with dicholromethane.The analysis is carried out by fused silica capillary gas chromatography using a 63Ni-electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240070202
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