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  • Electronic Resource  (2)
  • Antarctic snailfish  (1)
  • Chalone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Gewebsspezifische Hemmung der Lymphocytenproliferation durch Milzextrakt (Lymphocytenchalon) (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 221-226 
    Details
    ISSN: 1432-1440
    Keywords: Chalone ; Con A-Sepharose ; Graft versus host reaction ; Lymphocyte inhibiting factor ; PHA stimulation ; Spleen extract ; Chalon ; Con A-Sepharose ; Graft versus host reaction ; Lymphocyten-Hemmfaktor ; Milzextrakt ; PHA-Stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wäßrige Extrakte aus Kalbsmilz wurden durch Azetonfällung, Membranfiltration, Affinitätschromatographie und Dialyse gereinigt. Diese Extrakte hemmten den Thymidineinbau in lymphoiden Zellen (MKT-CH und PHA-stimulierte Lymphocytenkulturen). Zellen nicht lymphatischen Gewebes (Melanomzellen Mel Ei 78 und Ehrlich-Ascites-Zellen) wurden nicht beeinflußt. Die Hemmung war reversibel, und die Reinextrakte wirkten nicht zytotoxisch. Die Extrakte entsprechen einem Chalon. Ihre mögliche Bedeutung für die Verhinderung der Graft versus host reaction und für die Behandlung lymphoproliferativer Erkrankungen wird diskutiert.
    Notes: Summary Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cells (MKT-CH and PHA-stimulated lymphocyte cultures). They did not influence non lymphoid tissues (melanoma cells Mel Ei 78 and Ehrlich ascites cells). The inhibition was reversible and the purified extracts were not cytotoxic. The extracts correspond to a chalone. Their importance for prevention of graft versus host reaction and for treatment of lymphoproliferative diseases is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469129
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Protein content and freezing avoidance properties of the subdermal extracellular matrix and serum of the Antarctic snailfish, Paraliparis devriesi (1995)
    Springer
    Fish physiology and biochemistry 14 (1995), S. 71-80 
    Details
    ISSN: 1573-5168
    Keywords: subdermal extracellular matrix ; biochemical composition ; proteins ; Antarctic snailfish ; Liparididae ; Paraliparis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Antarctic snailfish, Paraliparis devriesi (Liparididae), occupies an epibenthic habitat at a depth of 500–650 m in the subzero waters of McMurdo Sound, Antarctica. This species has watery (97%) gelatinous subdermal extracellular matrix (SECM) comprising a mean of 33.8% of the body weight, the largest known proportion of any adult fish. The protein concentration of the SECM was found to be 6–7 mg ml−1 (0.6–0.7% w/v). Separation of the polypeptides of the SECM by SDS-PAGE revealed 11 polypeptides ranging in relative molecular mass (Mr) from 67,000 to 13,000, with other unresolved polypeptides of less than 13,000. The isoelectric points of these proteins ranged from 4.85 to 8.05. Partial N-terminal amino acid sequence data were obtained for four of the major SECM polypeptides. The N-terminal amino acid sequences of three of these were not identical to or homologous with any other known sequences, whereas the N-terminal sequence of one polypeptide (Mr 51,000) was identical to partial sequence from the apolipoprotein A-I precursor of Atlantic salmon (Salmo salar). Although not isolated from either SECM or serum, melting point-freezing point behavior of body fluids suggest that Paraliparis possess modest amounts of a noncolligative antifreeze compound. Since relatively small amounts of antifreeze are present in the serum and even less in the SECM, freezing avoidance results from the combined effects of antifreeze and the elevated osmolality of body fluids. There are no special adaptations to prevent freezing in the superficially located high water content SECM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00004292
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    Paper (German National Licenses)
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